JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB152051

重组人CD272/BTLA蛋白

Recombinant Human CD272/BTLA protein

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human CD272/BTLA protein is a Human Fragment protein, in the 31 to 150 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

查看别名

CD272, B- and T-lymphocyte attenuator, B- and T-lymphocyte-associated protein, BTLA

关键信息

纯度

>95% SDS-PAGE

内毒素水平

< 1 EU/µg

表达系统

HEK 293 cells

标签

His tag C-Terminus

应用

HPLC, SDS-PAGE

applications

生物活性

No

访问

Q7Z6A9

不含动物源

No

不含载体蛋白

No

种属

Human

复溶

Reconstitute in PBS

存储溶液

pH: 7.4 Constituents: 99% Phosphate Buffer, 0.88% Sodium chloride

storage-buffer

style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column

产品详情

This product was previously labelled as CD272
style
left-column

序列信息

[{"sequence":"KESCDVQLYIKRQSEHSILAGDPFELECPVKYCANRPHVTWCKLNGTTCVKLEDRQTSWKEEKNISFFILHFEPVLPNDNGSYRCSANFQSNLIESHSTTLYVTGKQNELSDTAGREINLVDHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"14.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":150,"aminoAcidStart":31,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q7Z6A9","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
style
left-column

性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
A few weeks
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
False
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CD272 also known as BTLA (B and T Lymphocyte Attenuator) is an immunoregulatory protein with a mass approximately 34 kDa. This target is part of the CD28 immunoglobulin superfamily and is expressed on the surfaces of various immune cells including T cells B cells and dendritic cells. BTLA/CD272 serves as a co-inhibitory molecule important in maintaining immune homeostasis. Its expression is influenced by factors present in the microenvironment of immune tissues.
Biological function summary

BTLA functions as a negative regulator of immune responses by delivering inhibitory signals to immune cells upon binding to its ligand HVEM (Herpesvirus entry mediator). It forms a part of an immunological checkpoint complex that modulates lymphocyte activity to prevent overactivation and autoimmunity. This mechanism helps maintain a balance between immune defense and tolerance contributing to self-tolerance.

Pathways

The BTLA/CD272 protein engages with pathways involved in immune checkpoints and T-cell receptor signaling. It interacts with proteins like HVEM and collaborates with receptors such as PD-1 and CTLA-4. These interactions play a role in the downregulation of T-cell responses which is essential in various immune processes. The signaling pathways influenced by BTLA/CD272 are integral in moderating immune responses cooperation and adaptation.

BTLA is associated with autoimmune diseases and cancer. In autoimmune disorders an altered expression or function of BTLA can lead to dysregulated immune responses causing tissue damage. In cancer the protein may contribute to immune evasion by tumors aiding tumor growth and progression. The interplay of BTLA with proteins such as PD-1 makes it a potential target for immunotherapy strategies in oncology and autoimmunity treatments.
style
left-column

特殊说明

形式

Lyophilized

附加说明

Purity is greater than 95% as determined by SEC-HPLC and reducing SDS-PAGE.

style
left-column

常规信息

功能

Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed : 12796776, PubMed : 14652006, PubMed : 15568026, PubMed : 18193050). May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed : 19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed : 19915044).

翻译后修饰

Phosphorylated on Tyr residues by TNFRSF14 and by antigen receptors cross-linking, both inducing association with PTPN6 and PTPN11.. N-glycosylated.

style
left-column

产品实验方案

style
left-column

靶点信息

Inhibitory receptor on lymphocytes that negatively regulates antigen receptor signaling via PTPN6/SHP-1 and PTPN11/SHP-2 (PubMed : 12796776, PubMed : 14652006, PubMed : 15568026, PubMed : 18193050). May interact in cis (on the same cell) or in trans (on other cells) with TNFRSF14 (PubMed : 19915044). In cis interactions, appears to play an immune regulatory role inhibiting in trans interactions in naive T cells to maintain a resting state. In trans interactions, can predominate during adaptive immune response to provide survival signals to effector T cells (PubMed : 19915044).
See full target information BTLA
style
left-column
style
left-column
style
right-column

搭配使用产品

Proteins & Peptides

AB307790

Recombinant Human Poliovirus Receptor/PVR Protein (His-tag) (Active)

Premium Bioactive

Biological Activity - Recombinant Human Poliovirus Receptor/PVR Protein (His-tag) (Active) (AB307790)

  • 0
  • 0
Proteins & Peptides

AB163782

Recombinant Human VISTA protein

SDS-PAGE - Recombinant Human VISTA protein (AB163782)

  • 0
  • 0
Proteins & Peptides

AB283931

Recombinant Human TNFL9 Protein (Active)

Bioactive

Functional Studies - Recombinant Human TNFL9 Protein (Active) (AB283931)

  • 0
  • 0
Primary Antibodies

AB230976

Anti-CD272/BTLA antibody [EPR22224-271]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD272/BTLA antibody [EPR22224-271] (AB230976)

  • 0
  • 0

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com