重组人CCN3蛋白
Recombinant Human CCN3 protein
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Recombinant Human CCN3 protein is a Human Fragment protein, in the 260 to 357 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, ELISA, WB.
查看别名
IGFBP9, NOV, NOVH, CCN3, CCN family member 3, Cellular communication network factor 3, Insulin-like growth factor-binding protein 9, Nephro blastoma-overexpressed gene protein homolog, Protein NOV homolog, IBP-9, IGF-binding protein 9, IGFBP-9, NovH
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human CCN3 protein (AB79564)
ab79564 on 15% SDS PAGE gel, Coomassie blue staining.
搭配使用产品
反应性数据
序列信息
性能和储存信息
形式
运输条件
推荐的短期储存条件
推荐的长期储存条件
分装信息
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
CCN3 influences several aspects of cell behavior including proliferation differentiation and migration. It does not function as part of a larger complex but acts as an individual entity facilitating communication between cells and the extracellular matrix. CCN3 also affects angiogenesis a critical process in both health and disease by modulating vascular endothelial growth factor (VEGF) pathways therefore impacting blood vessel formation and maintenance.
Pathways
CCN3 interacts primarily with key signaling pathways such as Wnt and TGF-beta signaling. Within the Wnt pathway CCN3 serves as a regulatory component modulating the activity of other proteins involved in cell growth. Similarly in the TGF-beta pathway it contributes to the regulation of cellular proliferation and differentiation by affecting interactions with other proteins like SMADs which are signal transducers in TGF-beta signaling.
常规信息
功能
Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PubMed : 12050162, PubMed : 12695522, PubMed : 15181016, PubMed : 15611078, PubMed : 21344378). Acts by binding to integrins or membrane receptors such as NOTCH1 (PubMed : 12695522, PubMed : 15611078, PubMed : 21344378). Essential regulator of hematopoietic stem and progenitor cell function (PubMed : 17463287). Inhibits myogenic differentiation through the activation of Notch-signaling pathway (PubMed : 12050162). Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling (PubMed : 20139355). Ligand of integrins ITGAV : ITGB3 and ITGA5 : ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival (PubMed : 12695522). Also plays a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5 : ITGB1 and ITGA6 : ITGB1 and induces fibroblast chemotaxis through ITGAV : ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PubMed : 15611078). Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed : 21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (PubMed : 21063504). Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (PubMed : 21871891). Brain osteoanabolic hormone (By similarity). Drives osteogenesis in osteochondral skeletal stem cells (PubMed : 38987585). During lactation, maintains the maternal skeleton and viability of offspring (By similarity).
序列相似性
Belongs to the CCN family.
翻译后修饰
May be palmitoylated on Cys-244, which is important for extracellular secretion.
靶点信息
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