重组人 Cbl-c 蛋白 (DDDDK tag N-Terminus)
Recombinant Human Cbl-c protein (DDDDK tag N-Terminus)
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Recombinant Human Cbl-c protein (DDDDK tag N-Terminus) is a Human Fragment protein, in the 11 to 404 aa range, expressed in HEK 293 cells, with >90%, suitable for SDS-PAGE.
查看别名
CBL3, RNF57, CBLC, E3 ubiquitin-protein ligase CBL-C, RING finger protein 57, RING-type E3 ubiquitin transferase CBL-C, SH3-binding protein CBL-3, SH3-binding protein CBL-C, Signal transduction protein CBL-C
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human Cbl-c protein (DDDDK tag N-Terminus) (AB271396)
SDS-PAGE analysis of ab271396.
反应性数据
序列信息
性能和储存信息
运输条件
推荐的短期储存条件
推荐的长期储存条件
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Cbl-c interacts with signaling complexes and modulates signal transduction pathways. It participates in processes such as negative regulation of tyrosine kinase signaling. Cbl-c operates alongside other proteins in the Cbl family including Cbl and Cbl-b to downregulate signaling through ubiquitination. It plays a significant role in the regulation of cellular growth and differentiation by targeting specific proteins for degradation.
Pathways
Cbl-c interacts with cellular signaling mechanisms involved in the regulation of growth and cellular response. Cbl-c is an important component of pathways like the Epidermal Growth Factor Receptor (EGFR) signaling pathway and the Insulin signaling pathway. Through these pathways Cbl-c also interacts with receptor tyrosine kinases such as EGFR and insulin receptors impacting cellular processes like proliferation migration and apoptosis.
特殊说明
形式
Liquid
常规信息
功能
Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Functionally coupled with the E2 ubiquitin-protein ligases UB2D1, UB2D2 and UB2D3. Regulator of EGFR mediated signal transduction; upon EGF activation, ubiquitinates EGFR. Isoform 1, but not isoform 2, inhibits EGF stimulated MAPK1 activation. Promotes ubiquitination of SRC phosphorylated at 'Tyr-419'. In collaboration with CD2AP may act as regulatory checkpoint for Ret signaling by modulating the rate of RET degradation after ligand activation; CD2AP converts it from an inhibitor to a promoter of RET degradation; the function limits the potency of GDNF on neuronal survival.
翻译后修饰
Phosphorylated on multiple tyrosine residues by SRC. Isoform 1, but not isoform 2, is phosphorylated on tyrosines by EGFR.. Autoubiquitinated when phosphorylated at Tyr-341, enhanced by SRC; suggesting proteasomal degradation.
靶点信息
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