JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB177726

重组人 CAMK2N1 蛋白 (His tag N-Terminus)

Recombinant Human CAMK2N1 protein (His tag N-Terminus)

Be the first to review this product! Submit a review

|

(0 Publication)

Recombinant Human CAMK2N1 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 78 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

查看别名

Calcium/calmodulin-dependent protein kinase II inhibitor 1, CaMKII inhibitory protein alpha, CaMKIIN-alpha, CAMK2N1

1 Images
SDS-PAGE - Recombinant Human CAMK2N1 protein (His tag N-Terminus) (AB177726)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human CAMK2N1 protein (His tag N-Terminus) (AB177726)

15% SDS-PAGE analysis of ab177726 (3μg).

关键信息

纯度

>90% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE, Mass Spec

applications

生物活性

No

访问

Q7Z7J9

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column
style
left-column

序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMSEVLPYGDEKLSPYGDGGDVGQIFSCRLQDTNNFFGAGQNKRPPKLGQIGRSKRVVIEDDRIDDVLKNMTDKAPPGV","proteinLength":"Full Length","predictedMolecularWeight":"10.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":78,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q7Z7J9","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
style
left-column

性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CAMK2N1 also known as calcium/calmodulin-dependent protein kinase II inhibitor 1 is a small protein with a molecular weight of approximately 8 kDa. It acts as a natural inhibitor of the CaMKII enzyme an important kinase involved in calcium signaling. CAMK2N1 binds to the CaMKII holoenzyme inhibiting its activity by blocking its substrate access. The protein is mainly expressed in the brain particularly in regions such as the hippocampus where calcium signaling plays a critical role in neuronal plasticity.
Biological function summary

CAMK2N1 influences calcium-mediated neuronal signaling by regulating CaMKII activity. It does not act alone; instead it is part of a larger signaling complex that modulates synaptic strength and plasticity. Its inhibitory action on CaMKII affects processes associated with learning and memory by controlling the extent of phosphorylation events at synapses. As a result CAMK2N1 has an important role in maintaining neuronal function and homeostasis.

Pathways

CAMK2N1 is significant in the calcium signaling pathway and the long-term potentiation pathway. By modulating CaMKII activity CAMK2N1 influences various downstream events including the phosphorylation of target proteins such as CREB and synapsin. These events are essential for synaptic plasticity and memory formation. The regulation of CaMKII by CAMK2N1 along with its interaction with other kinases and phosphatases integrates signals that are necessary for synaptic modification.

CAMK2N1 has been linked to neurological conditions like Alzheimer's disease and schizophrenia. In Alzheimer’s disease dysregulation of calcium signaling and impaired synaptic plasticity are observed connecting CAMK2N1 and CaMKII activities to the disease's progression. Similarly in schizophrenia alterations in synaptic function and signaling have been noted involving CAMK2N1’s regulation of CaMKII. The interplay between CAMK2N1 and other proteins in these pathways such as tau in Alzheimer's and dopamine receptors in schizophrenia highlights its potential role in these disorders.
style
left-column

特殊说明

形式

Liquid

style
left-column

常规信息

功能

Potent and specific inhibitor of CaM-kinase II (CAMK2) (By similarity). Plays a role in the maintenance of long-term retrieval-induced memory in response to contextual fear (By similarity). Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of left ventricular mass (By similarity). Mediates the NLRP3 inflammasome in cardiomyocytes via acting as an inhibitor of the MAPK14/p38 and MAPK8/JNK pathways, thereby regulating ventricular remodeling and cardiac rhythm post-myocardial infarction (By similarity). Negatively effects insulin sensitivity and promotes lipid formation in adipose tissues independent of CAMK2 signaling (By similarity).

序列相似性

Belongs to the CAMK2N family.

style
left-column

产品实验方案

style
left-column

靶点信息

Potent and specific inhibitor of CaM-kinase II (CAMK2) (By similarity). Plays a role in the maintenance of long-term retrieval-induced memory in response to contextual fear (By similarity). Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of left ventricular mass (By similarity). Mediates the NLRP3 inflammasome in cardiomyocytes via acting as an inhibitor of the MAPK14/p38 and MAPK8/JNK pathways, thereby regulating ventricular remodeling and cardiac rhythm post-myocardial infarction (By similarity). Negatively effects insulin sensitivity and promotes lipid formation in adipose tissues independent of CAMK2 signaling (By similarity).
See full target information Calcium/calmodulin-dependent protein kinase II inhibitor 1
style
left-column
style
left-column
style
right-column

搭配使用产品

Proteins & Peptides

AB219489

Recombinant Human EDA2R/XEDAR protein (Fc tag C-Terminus + His tag C-Terminus)

SDS-PAGE - Recombinant Human EDA2R/XEDAR protein (Fc tag C-Terminus + His tag C-Terminus) (AB219489)

  • 0
  • 0
Proteins & Peptides

AB219446

Recombinant Human CRALBP protein (His tag C-Terminus)

SDS-PAGE - Recombinant Human CRALBP protein (His tag C-Terminus) (AB219446)

  • 0
  • 0
Secondary Antibodies

AB125919

Rabbit monoclonal [H19-5] Anti-Human kappa light chain

RabMAb|Recombinant

Western blot - Rabbit monoclonal [H19-5] Anti-Human kappa light chain (AB125919)

  • 0
  • 0
Proteins & Peptides

AB174421

Recombinant Human TAZ protein (denatured) (His tag N-Terminus)

SDS-PAGE - Recombinant Human TAZ protein (denatured) (His tag N-Terminus) (AB174421)

  • 0
  • 0

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com