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AB132175

重组人 CAB3 蛋白 (GST tag N-Terminus)

Recombinant Human CAB3 protein (GST tag N-Terminus)

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Recombinant Human CAB3 protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 484 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

查看别名

CACNLB3, CACNB3, Voltage-dependent L-type calcium channel subunit beta-3, CAB3, Calcium channel voltage-dependent subunit beta 3

1 Images
SDS-PAGE - Recombinant Human CAB3 protein (GST tag N-Terminus) (AB132175)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human CAB3 protein (GST tag N-Terminus) (AB132175)

12.5% SDS-PAGE analysis of ab132175 stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

标签

GST tag N-Terminus

应用

ELISA, WB, SDS-PAGE

applications

生物活性

No

访问

P54284

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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产品详情

This product was previously labelled as CACNB3.
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序列信息

[{"sequence":"MYDDSYVPGFEDSEAGSADSYTSRPSLDSDVSLEEDRESARREVESQAQQQLERAKHKPVAFAVRTNVSYCGVLDEECPVQGSGVNFEAKDFLHIKEKYSNDWWIGRLVKEGGDIAFIPSPQRLESIRLKQEQKARRSGNPSSLSDIGNRRSPPPSLAKQKQKQAEHVPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFDGRISITRVTADLSLAKRSVLNNPGKRTIIERSSARSSIAEVQSEIERIFELAKSLQLVVLDADTINHPAQLAKTSLAPIIVFVKVSSPKVLQRLIRSRGKSQMKHLTVQMMAYDKLVQCPPESFDVILDENQLEDACEHLAEYLEVYWRATHHPAPGPGLLGPPSAIPGLQNQQLLGERGEEHSPLERDSLMPSDEASESSRQAWTGSSQRSSRHLEEDYADAYQDLYQPHRQHTSGLPSANGHDPQDRLLAQDSEHNHSDRNWQRNRPWPKDSY","proteinLength":"Full Length","predictedMolecularWeight":"80.9 kDa","actualMolecularWeight":null,"aminoAcidEnd":484,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P54284","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

CAB3 also known as calcineurin B homologous protein 3 (CaCNB3) is a protein involved in intracellular signaling. The protein weighs approximately 22 kDa and expresses in various tissues including the heart and brain. Functionally CAB3 participates in calcium-binding and signaling processes facilitating interactions essential for cellular responses to changes in calcium levels.
Biological function summary

CAB3 plays an integral role in calcium-dependent signaling pathways. This protein functions as part of a larger calcineurin complex alongside calcineurin A. CAB3 and the complex it forms modulate the activity of several downstream targets influencing cellular processes like gene expression and cytoskeletal dynamics. In neurons CAB3 contributes to the synaptic plasticity necessary for learning and memory.

Pathways

CAB3 is an important component in calcium and NFAT signaling pathways. It directly regulates these pathways impacting gene expression and cellular development. CAB3 interacts with other proteins like calmodulin which facilitates its binding and functional actions within the pathway. Through modulation of these pathways CAB3 participates in orchestrating cellular responses to external stimuli.

Mutations or dysregulation of CAB3 relate to cardiac hypertrophy and neurodegenerative diseases such as Alzheimer’s. Misregulation of CAB3 activity can disrupt calcium homeostasis aggravating disease processes. The connection to calcineurin is significant as alterations in this relationship could influence the progression of these disorders offering potential targets for therapeutic intervention.
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特殊说明

形式

Liquid

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常规信息

功能

Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed : 8119293). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity).

序列相似性

Belongs to the calcium channel beta subunit family.

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产品实验方案

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靶点信息

Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed : 8119293). Increases CACNA1B peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity). Increases CACNA1C peak calcium current and shifts the voltage dependencies of channel activation and inactivation (By similarity).
See full target information CACNB3
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搭配使用产品

Cell Lines & Lysates

AB265180

Human CACNB3 (CAB3) knockout HeLa cell line

Sanger Sequencing - Human CACNB3 (CAB3) knockout HeLa cell line (AB265180)

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Cell Lines & Lysates

AB263132

Human CACNB3 (CAB3) knockout HeLa cell lysate

Sanger Sequencing - Human CACNB3 (CAB3) knockout HeLa cell lysate (AB263132)

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