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AB168089

重组人C17orf81蛋白

Recombinant Human C17orf81 protein

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Recombinant Human C17orf81 protein is a Human Full Length protein, in the 1 to 316 aa range, expressed in Escherichia coli, with >80%, suitable for SDS-PAGE, Mass Spec.

查看别名

C17orf81, DERP6, HSPC002, MSTP071, ELP5, Elongator complex protein 5, Dermal papilla-derived protein 6, S-phase 2 protein

1 Images
SDS-PAGE - Recombinant Human C17orf81 protein (AB168089)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human C17orf81 protein (AB168089)

15% SDS-PAGE analysis of ab168089 (3 µg).

关键信息

纯度

>80% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE, Mass Spec

applications

生物活性

No

访问

Q8TE02

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 20% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMTPSEGARAGTGRELEMLDSLLALGGLVLLRDSVEWEGRSLLKALVKKSALCGEQVHILGCEVSEEEFREGFDSDINNRLVYHDFFRDPLNWSKTEEAFPGGPLGALRAMCKRTDPVPVTIALDSLSWLLLRLPCTTLCQVLHAVSHQDSCPGDSSSVGKVSVLGLLHEELHGPGPVGALSSLAQTEVTLGGTMGQASAHILCRRPRQRPTDQTQWFSILPDFSLDLQEGPSVESQPYSDPHIPPVDPTTHLTFNLHLSKKEREARDSLILPFQFSSEKQQALLRPRPGQATSHIFYEPDAYDDLDQEDPDDDLDI","proteinLength":"Full Length","predictedMolecularWeight":"37.2 kDa","actualMolecularWeight":null,"aminoAcidEnd":316,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8TE02","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

C17orf81 also known as chromosome 17 open reading frame 81 is a protein that functions at the cellular level although its exact mechanical role is still under investigation. The protein has a molecular weight of approximately 30 kDa. Expression of C17orf81 occurs in various human tissues suggesting it may have roles in multiple cellular contexts. Researchers have observed its presence in tissues like the brain and liver indicating its potential significance in these organs.
Biological function summary

C17orf81 adds significance to cellular processes by participating in complex mechanisms that are not yet fully defined. This protein as evidence suggests might interact with other proteins to support cellular functions but its exact biological role requires more study. Current research focuses on understanding these interactions better to clarify the complex pathways C17orf81 influences.

Pathways

Several research studies indicate C17orf81's involvement in cellular signaling and metabolic pathways like the PI3K-Akt pathway. This pathway is important in regulating various cellular activities including cell growth and survival. C17orf81 may also interact with other proteins such as Akt an important signaling protein in this pathway which suggests cooperation in cellular functions. This connection points towards an importance in maintaining cellular balance and responding to external stimuli.

C17orf81's interactions may link it to certain cancers and neurodegenerative diseases. Its potential association with disorders such as glioblastoma highlights its influence in disease progression. In the context of neurodegenerative diseases C17orf81 relates to proteins like tau which are involved in such disorders. Understanding these connections better can aid in identifying therapeutic targets for these conditions.
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特殊说明

形式

Liquid

附加说明

ab168089 was purified using conventional chromatography techniques.

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常规信息

功能

Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed : 29332244). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed : 29332244). Involved in cell migration (By similarity).

序列相似性

Belongs to the ELP5 family.

翻译后修饰

Tyrosine-phosphorylated.

亚细胞定位

Nucleus

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产品实验方案

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靶点信息

Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed : 29332244). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed : 29332244). Involved in cell migration (By similarity).
See full target information ELP5
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