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AB167848

重组人BSND蛋白

Recombinant Human BSND protein

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Recombinant Human BSND protein is a Human Fragment protein, in the 54 to 320 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.

查看别名

BART, BSND, Barttin

1 Images
SDS-PAGE - Recombinant Human BSND protein (AB167848)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human BSND protein (AB167848)

15% SDS-PAGE analysis of 3µg ab167848.

关键信息

纯度

>90% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE, Mass Spec

applications

生物活性

No

访问

Q8WZ55

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.88% Sodium chloride, 0.32% Tris HCl, 0.02% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "Mass Spec": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MGSSHHHHHHSSGLVPRGSHMGSCQCYPKITFVPADSDFQGILSPKAMGLLENGLAAEMKSPSPQPPYVRLWEEAAYDQSLPDFSHIQMKVMSYSEDHRSLLAPEMGQPKLGTSDGGEGGPGDVQAWMEAAVVIHKGSDESEGERRLTQSWPGPLACPQGPAPLASFQDDLDMDSSEGSSPNASPHDREEACSPQQEPQGCRCPLDRFQDFALIDAPTLEDEPQEGQQWEIALPNNWQRYPRTKVEEKEASDTGGEEPEKEEEDLYYGLPDGAGDLLPDKELGFEPDTQG","proteinLength":"Fragment","predictedMolecularWeight":"31.7 kDa","actualMolecularWeight":null,"aminoAcidEnd":320,"aminoAcidStart":54,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q8WZ55","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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特殊说明

形式

Liquid

附加说明

ab167848 was purified using conventional chromatography techniques.

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常规信息

功能

Regulatory subunit of anion-selective CLCNKA : BSND and CLCNKB : BSND heteromeric channels involved in basolateral chloride conductance along the nephron to achieve urine concentration and maintain systemic acid-base homeostasis, and in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing (PubMed : 11734858, PubMed : 12111250, PubMed : 12574213, PubMed : 16849430, PubMed : 18776122, PubMed : 19646679, PubMed : 20538786, PubMed : 26013830). Most likely acts as a chaperone that allosterically regulates proper sorting of CLCNKA : BSND and CLCNKB : BSND channels at the basolateral plasma membrane domain and functional switch to ion conducting state. Mediates constitutive opening of channel common gates (PubMed : 11734858, PubMed : 12111250, PubMed : 12574213, PubMed : 16849430, PubMed : 18776122, PubMed : 19646679, PubMed : 20538786, PubMed : 26013830).

翻译后修饰

Palmitoylation is necessary for activation of plasma membrane-inserted CLC-K/barttin channels.

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产品实验方案

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靶点信息

Regulatory subunit of anion-selective CLCNKA : BSND and CLCNKB : BSND heteromeric channels involved in basolateral chloride conductance along the nephron to achieve urine concentration and maintain systemic acid-base homeostasis, and in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing (PubMed : 11734858, PubMed : 12111250, PubMed : 12574213, PubMed : 16849430, PubMed : 18776122, PubMed : 19646679, PubMed : 20538786, PubMed : 26013830). Most likely acts as a chaperone that allosterically regulates proper sorting of CLCNKA : BSND and CLCNKB : BSND channels at the basolateral plasma membrane domain and functional switch to ion conducting state. Mediates constitutive opening of channel common gates (PubMed : 11734858, PubMed : 12111250, PubMed : 12574213, PubMed : 16849430, PubMed : 18776122, PubMed : 19646679, PubMed : 20538786, PubMed : 26013830).
See full target information BSND
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