重组人BMPR1A蛋白(ab105907)
Key features and details
- Expression system: Baculovirus infected Sf9 cells
- Purity: > 90% Densitometry
- Active: Yes
- Suitable for: WB, Functional Studies
描述
-
产品名称
重组人BMPR1A蛋白
参阅全部 BMPR1A 蛋白酶 -
生物活性
The Specific activity of ab105907 was determined to be 1.2 nmol/min/mg.
-
纯度
> 90 % Densitometry.
Purity was determined to be >90% by densitometry. Affinity purified. -
表达系统
Baculovirus infected Sf9 cells -
Accession
-
蛋白长度
Protein fragment -
无动物成分
No -
性质
Recombinant -
-
种属
Human -
预测分子量
66 kDa including tags -
氨基酸
187 to 532
-
相关产品
-
Substrate reagent
技术指标
Our Abpromise guarantee covers the use of ab105907 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
-
应用
Western blot
Functional Studies
-
形式
Liquid -
补充说明
ab204884 (Smad3 peptide) can be utilized as a substrate for assessing kinase activity
-
Concentration information loading...
制备和贮存
-
稳定性和存储
Shipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
pH: 7.50
Constituents: 0.307% Glutathione, 0.00174% PMSF, 0.00385% DTT, 0.79% Tris HCl, 0.00292% EDTA, 25% Glycerol (glycerin, glycerine), 0.87% Sodium chlorideThis product is an active protein and may elicit a biological response in vivo, handle with caution.
常规信息
-
别名
- 10q23del
- Activin A receptor type II like kinase 3
- Activin receptor like kinase 3
see all -
功能
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. -
组织特异性
Highly expressed in skeletal muscle. -
疾病相关
Juvenile polyposis syndrome
Polyposis syndrome, mixed hereditary 2
A microdeletion of chromosome 10q23 involving BMPR1A and PTEN is a cause of chromosome 10q23 deletion syndrome, which shows overlapping features of the following three disorders: Bannayan-Zonana syndrome, Cowden disease and juvenile polyposis syndrome. -
序列相似性
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain. -
细胞定位
Membrane. - Information by UniProt
图片
-
Functional Studies - Recombinant human BMPR1A protein (ab105907)The specific activity of BMPR1A (ab105907) was determined to be 1.4 nmol/min/mg as per activity assay protocol
-
SDS-PAGE - Recombinant human BMPR1A protein (ab105907)SDS PAGE analysis of ab105907 -
SDS-PAGE - Recombinant human BMPR1A protein (ab105907)SDS PAGE analysis of ab105907 -
Functional Studies - Recombinant human BMPR1A protein (ab105907)Kinase Assay demonstrating specific activity of ab105907 at 1.2 nmol/min/mg. -
SDS-PAGE - Recombinant human BMPR1A protein (ab105907)SDS-PAGE showing ab105907 at approximately 66kDa.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
-
SDS download
-
Datasheet download
文献 (0)
ab105907 尚未被引用在任何文献中。