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AB116891

重组人 Blood Group Kell Antigen 蛋白 (GST tag N-Terminus)

Recombinant Human Blood Group Kell Antigen protein (GST tag N-Terminus)

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Recombinant Human Blood Group Kell Antigen protein (GST tag N-Terminus) is a Human Full Length protein, in the 1 to 732 aa range, expressed in Wheat germ, suitable for SDS-PAGE, ELISA, WB.

查看别名

CD238, Kell blood group glycoprotein, KEL

1 Images
SDS-PAGE - Recombinant Human Blood Group Kell Antigen protein (GST tag N-Terminus) (AB116891)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Blood Group Kell Antigen protein (GST tag N-Terminus) (AB116891)

12.5% SDS-PAGE showing ab116891 at approximately 106.59kDa stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

标签

GST tag N-Terminus

应用

WB, SDS-PAGE, ELISA

applications

生物活性

No

访问

P23276

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.3% Glutathione

storage-buffer

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搭配使用产品

Primary Antibodies

AB90456

Anti-Blood Group Kell Antigen antibody [MM0435-12X3]

Western blot - Anti-Blood Group Kell Antigen antibody [MM0435-12X3] (AB90456)

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Proteins & Peptides

AB277017

Recombinant Mouse Calnexin protein (His tag)

SDS-PAGE - Recombinant Mouse Calnexin protein (His tag) (AB277017)

  • 0
  • 0
Proteins & Peptides

AB162110

Recombinant Human IL-17C protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human IL-17C protein (GST tag N-Terminus) (AB162110)

  • 0
  • 0
Proteins & Peptides

AB159810

Recombinant Human WHSC1/NSD2 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human WHSC1/NSD2 protein (GST tag N-Terminus) (AB159810)

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p>Recombinant protein.</p>" } } }
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序列信息

[{"linker":null,"sequence":"MEGGDQSEEEPRERSQAGGMGTLWSQESTPEERLPVEGSRPWAVARRVLTAILILGLLLCFSVLLFYNFQNCGPRPCETSVCLDLRDHYLASGNTSVAPCTDFFSFACGRAKETNNSFQELATKNKNRLRRILEVQNSWHPGSGEEKAFQFYNSCMDTLAIEAAGTGPLRQVIEELGGWRISGKWTSLNFNRTLRLLMSQYGHFPFFRAYLGPHPASPHTPVIQIDQPEFDVPLKQDQEQKIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLRPLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQLVEEMLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTFFEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMGASEWALKPELARQEYNDIQLGSSFLQSVLSCVRSLRARIVQSFLQPHPQHRWKVSPWDVNAYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCLACDNHALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAYSKRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDSHDTHSPPHLRVHGPLSSTPAFARYFRCARGALLNPSSRCQLW","proteinLength":"Full Length","predictedMolecularWeight":"106.59 kDa","actualMolecularWeight":null,"aminoAcidEnd":732,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P23276","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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性能和储存信息

形式
Liquid
纯化工艺
Proprietary technique
运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The Blood Group Kell Antigen also known as Kell protein is a type II transmembrane glycoprotein with a mass of approximately 93 kDa. It exists on the surface of red blood cells (RBCs) and has enzymatic activity specifically as a zinc endopeptidase. The primary expression site for Kell protein is the erythrocyte membrane where it functions in processing various polypeptides through its enzymatic action. There are different phenotypes like Kell positive and Kell negative and antibodies such as anti-Kell and anti-K are significant in immunohematology.
Biological function summary

The Kell protein facilitates the degradation of endothelin precursors. It belongs to the neprilysin (M13) family of zinc endopeptidases playing a critical part in modulating vasoactive peptides. Normally the Kell protein forms a complex with another protein called XK an integral membrane protein. When properly functioning this Kell-XK complex maintains RBC integrity and membrane flexibility essential for normal cellular operations and lifespan.

Pathways

The Kell antigen influences pathways involved in cardiovascular regulation and cellular movement. It has connections with the vasoregulatory pathway where it interacts with endothelins. The breakdown of endothelin precursors by Kell reduces the levels of these potent vasoconstrictors. The protein also has an indirect association with members of the endothelin-converting enzyme family which further processes these peptides into active forms.

The Kell antigen plays an important role in conditions like transfusion reactions and hemolytic disease of the newborn (HDN). In transfusion medicine incompatibility with Kell positive blood can lead to antibody production resulting in hemolytic reactions. Anti-Kell antibodies such as anti-K and anti-Kell are particularly implicated in HDN where the maternal immune response targets the Kell antigen on fetal erythrocytes. The XK protein related to Kell through the disease mechanism is also involved and mutations in XK can cause McLeod syndrome further complicating blood group antigen relationships.
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常规信息

功能

Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3.

序列相似性

Belongs to the peptidase M13 family.

翻译后修饰

N-glycosylated.

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产品实验方案

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靶点信息

Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3.
See full target information KEL
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