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AB157919

重组人ASIP蛋白

Recombinant Human ASIP protein

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Recombinant Human ASIP protein is a Human Fragment protein, in the 33 to 132 aa range, expressed in Wheat germ, suitable for ELISA, WB.

查看别名

AGTI, AGTIL, ASP, ASIP, Agouti-signaling protein, Agouti switch protein

1 Images
SDS-PAGE - Recombinant Human ASIP protein (AB157919)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human ASIP protein (AB157919)

ab157919 on a 12.5% SDS-PAGE stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

标签

GST tag N-Terminus

应用

ELISA, WB

applications

生物活性

No

访问

P42127

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"DRSLRSNSSVNLLDVPSVSIVALNKKSKQIGRKAAEKKRSSKKEASMKKVVRPRTPLSAPCVATRNSCKPPAPACCDPCASCQCRFFRSACSCRVLSLNC","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":132,"aminoAcidStart":33,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P42127","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The agouti signaling protein (ASIP) also known as agouti protein or agouti switch protein functions mechanically as an antagonist to the melanocortin 1 receptor (MC1R). This interaction influences pigmentation processes by modulating eumelanin and pheomelanin production. ASIP possesses a mass of approximately 14 kDa. It is expressed in several tissues such as skin adipose tissue and neural tissues highlighting its varied roles in different biological contexts.
Biological function summary

ASIP plays an important role in pigmentation regulation and energy homeostasis. It prevents MC1R from binding its ligand alpha-melanocyte-stimulating hormone (α-MSH) leading to lightening of skin and fur coloration by shifting melanin production from eumelanin to pheomelanin. Although ASIP is not part of a larger protein complex its interaction with the MC1R receptor greatly influences pigmentation phenotypes.

Pathways

ASIP integrates into the melanocortin signaling pathway which regulates skin and hair color as well as energy expenditure. It interacts with key pathway proteins such as MC1R and α-MSH driving the balance between pigmentation and metabolic activity. ASIP’s role extends to pathways related to lipid metabolism linking it to proteins involved in energy balance and adiposity.

ASIP shows association with conditions such as obesity and melanoma. Its influence on energy homeostasis implicates it in the development of obesity where altered ASIP expression affects lipid storage and metabolism. ASIP’s interaction with MC1R also ties it to melanoma risk as changes in its activity might predispose individuals to pigmentation disorders influencing melanoma susceptibility. These interactions showcase ASIP’s connection to disease states through its modulation of receptor-related functions.
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特殊说明

形式

Liquid

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常规信息

功能

Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.

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产品实验方案

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靶点信息

Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes.
See full target information ASIP
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