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AB196049

重组人ARHGAP25蛋白

Recombinant Human ARHGAP25 protein

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Recombinant Human ARHGAP25 protein is a Human Fragment protein, in the 1 to 458 aa range, expressed in HEK 293 cells, with >95%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, HPLC.

查看别名

KIAA0053, ARHGAP25, Rho GTPase-activating protein 25, Rho-type GTPase-activating protein 25

关键信息

纯度

>95% SDS-PAGE

内毒素水平

< 1 EU/µg

表达系统

HEK 293 cells

标签

His tag C-Terminus

应用

SDS-PAGE, HPLC

applications

生物活性

No

访问

P42331

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 7.5 Constituents: 0.32% Tris HCl, 0.08% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.048% Magnesium chloride

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "HPLC": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MSLGQSACLFLSIARSRSVMTGEQMAAFHPSSTPNPLERPIKMGWLKKQRSIVKNWQQRYFVLRAQQLYYYKDEEDTKPQGCMYLPGCTIKEIATNPEEAGKFVFEIIPASWDQNRMGQDSYVLMASSQAEMEEWVKFLRRVAGTPCGAVFGQRLDETVAYEQKFGPHLVPILVEKCAEFILEHGRNEEGIFRLPGQDNLVKQLRDAFDAGERPSFDRDTDVHTVASLLKLYLRDLPEPVVPWSQYEGFLLCGQLTNADEAKAQQELMKQLSILPRDNYSLLSYICRFLHEIQLNCAVNKMSVDNLATVIGVNLIRSKVEDPAVIMRGTPQIQRVMTMMIRDHEVLFPKSKDIPLSPPAQKNDPKKAPVARSSVGWDATEDLRISRTDSFSSMVRCREPSCFHWVLPLVQAIPCKACSRVAIWGVLGDAVAVGAAATDSSEHTLKAWPLSKSSFYWHLVDHHHHHH","proteinLength":"Fragment","predictedMolecularWeight":"52.8 kDa","actualMolecularWeight":null,"aminoAcidEnd":458,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"P42331","tags":[{"tag":"His","terminus":"C-Terminus"}]}]
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性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ARHGAP25 also known as Rho GTPase-activating protein 25 functions mechanically as a GTPase activator for the Rho-family of small GTPases. This protein plays a role in switching these GTPases from an active state to an inactive state by stimulating the intrinsic GTPase activity. ARHGAP25 has a mass of approximately 61 kDa. It is expressed mainly in hematopoietic cells with specific expression in leukocytes. Its activity is important in cellular processes involving actin cytoskeletal reorganization.
Biological function summary

ARHGAP25 modulates the actin cytoskeleton impacting cell migration phagocytosis and other hematopoietic cell functions. It acts as a part of regulatory complexes that control cytoskeletal dynamics and cellular morphology. By regulating Rho family members like Rac1 and Cdc42 ARHGAP25 influences actin polymerization and cellular movement particularly in immune cells. This protein contributes to maintaining the integrity of immune responses.

Pathways

ARHGAP25 plays a role in the Rho GTPase signaling pathway and interacts with pathways that control cell division and migration. Within these networks ARHGAP25 interacts closely with proteins such as Rac1 and Cdc42 which are widely involved in actin dynamics and cell motility. This interaction impacts pathways that govern the reorganization of actin filaments important for leukocyte function and migration.

ARHGAP25 is involved in conditions like chronic inflammatory diseases and immune system dysregulation. Its dysregulated expression or function can lead to altered immune cell behavior and contribute to chronic inflammation. The protein's relationship with Rac1 and Cdc42 is significant as these proteins also associate with pathways implicated in immune dysfunction and inflammation. Understanding ARHGAP25's role provides insight into targeting therapies for disorders characterized by abnormal immune responses.
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特殊说明

形式

Liquid

附加说明

SEC-HPLC and reducing SDS-PAGE

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常规信息

功能

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.

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产品实验方案

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靶点信息

GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state.
See full target information ARHGAP25
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搭配使用产品

Primary Antibodies

AB251103

Anti-ARHGAP25 antibody [EPR13233-60] - BSA and Azide free

RabMAb|Recombinant

Western blot - Anti-ARHGAP25 antibody [EPR13233-60] - BSA and Azide free (AB251103)

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