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AB157901

重组人Aquaporin 7蛋白

Recombinant Human Aquaporin 7 protein

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Recombinant Human Aquaporin 7 protein is a Human Full Length protein, in the 1 to 342 aa range, expressed in Wheat germ, suitable for ELISA, WB.

查看别名

AQP7L, AQP9, AQP7, Aquaporin-7, AQP-7, Aquaglyceroporin-7, Aquaporin adipose, Aquaporin-7-like, AQPap

1 Images
SDS-PAGE - Recombinant Human Aquaporin 7 protein (AB157901)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Aquaporin 7 protein (AB157901)

ab157901 on a 12.5% SDS-PAGE stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

标签

GST tag N-Terminus

应用

WB, ELISA

applications

生物活性

No

访问

O14520

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MVQASGHRRSTRGSKMVSWSVIAKIQEILQRKMVREFLAEFMSTYVMMVFGLGSVAHMVLNKKYGSYLGVNLGFGFGVTMGVHVAGRISGAHMNAAVTFANCALGRVPWRKFPVYVLGQFLGSFLAAATIYSLFYTAILHFSGGQLMVTGPVATAGIFATYLPDHMTLWRGFLNEAWLTGMLQLCLFAITDQENNPALPGTEALVIGILVVIIGVSLGMNTGYAINPSRDLPPRIFTFIAGWGKQVFSNGENWWWVPVVAPLLGAYLGGIIYLVFIGSTIPREPLKLEDSVAYEDHGITVLPKMGSHEPTISPLTPVSVSPANRSSVHPAPPLHESMALEHF","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":342,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"O14520","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Aquaporin 7 (AQP7) sometimes referred to as AQPap is a protein channel that enables the transport of water and small molecules like glycerol across cell membranes. It has a molecular mass of approximately 28 kDa. This protein is widely expressed in adipose tissue kidney and testis where it facilitates critical cellular processes by regulating water and solute flow. The localization of AQP7 in these tissues highlights its key role in the body’s fluid management and metabolic regulation.
Biological function summary

AQP7 plays an important role in maintaining the balance of glycerol and water within cells which is essential for energy homeostasis. It does not function as part of a known complex but works as an individual tetrameric channel. In adipose tissue AQP7 facilitates the release of glycerol consequently affecting lipid metabolism and energy storage. This function contributes significantly to how organisms respond to energy demands and metabolic changes.

Pathways

AQP7 is critical in glycerol transport and lipid metabolism pathways impacting insulin signaling and glucose regulation. AQP7 is closely associated with proteins like adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) which regulate lipid breakdown and mobilization. The interplay between these proteins and AQP7 illustrates its importance in pathways that govern energy balance and metabolic flexibility affecting how cells use stored energy.

AQP7 has associations with metabolic conditions such as obesity and type 2 diabetes. Altered expression or functionality of AQP7 in adipose tissue can influence glycerol release and consequently lipid and glucose metabolism. Dysregulation of AQP7 may also impact metabolic processes by interacting with proteins involved in lipid metabolism like ATGL and HSL. These connections highlight the significance of AQP7 in understanding the molecular basis of metabolic diseases.
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特殊说明

形式

Liquid

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常规信息

功能

Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed : 11952783, PubMed : 30420639, PubMed : 30423801, PubMed : 36737436, PubMed : 9405233). Could also be permeable to urea (PubMed : 9405233). Mediates the efflux of glycerol, formed upon triglyceride hydrolysis, to avoid its accumulation in adipocytes and to make it available to other tissues. In the kidney, mediates the reabsorption of glycerol, preventing its loss in urine, again participating to energy homeostasis. In pancreatic beta cells, it also mediates the efflux of glycerol, regulating its intracellular levels (By similarity).

序列相似性

Belongs to the MIP/aquaporin (TC 1.A.8) family.

翻译后修饰

Phosphorylation by PKA could prevent the interaction with PLIN1.

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产品实验方案

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靶点信息

Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient (PubMed : 11952783, PubMed : 30420639, PubMed : 30423801, PubMed : 36737436, PubMed : 9405233). Could also be permeable to urea (PubMed : 9405233). Mediates the efflux of glycerol, formed upon triglyceride hydrolysis, to avoid its accumulation in adipocytes and to make it available to other tissues. In the kidney, mediates the reabsorption of glycerol, preventing its loss in urine, again participating to energy homeostasis. In pancreatic beta cells, it also mediates the efflux of glycerol, regulating its intracellular levels (By similarity).
See full target information AQP7
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