JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB113861

重组人Apolipoprotein A V/APOA5

Recombinant Human Apolipoprotein A V/APOA5

Be the first to review this product! Submit a review

|

(1 Publication)

Recombinant Human Apolipoprotein A V/APOA5 is a Human Full Length protein, in the 24 to 366 aa range, expressed in HEK 293 cells, with >70%, < 1 EU/µg endotoxin level, suitable for SDS-PAGE, ELISA, WB.

查看别名

RAP3, UNQ411/PRO773, APOA5, Apolipoprotein A-V, Apo-AV, ApoA-V, Apolipoprotein A5, Regeneration-associated protein 3

1 Images
SDS-PAGE - Recombinant Human Apolipoprotein A V/APOA5 (AB113861)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Apolipoprotein A V/APOA5 (AB113861)

12% SDS-PAGE separation of Human Apolipoprotein A V/APOA5
1.reduced and boiled sample, 5μg/lane
2.non-reduced and non-boiled sample, 5μg/lane

关键信息

纯度

>70% SDS-PAGE

Purity determined by densitometric image analysis

内毒素水平

< 1 EU/µg

表达系统

HEK 293 cells

标签

DDDDK tag C-Terminus

应用

SDS-PAGE, ELISA, WB

applications

生物活性

No

访问

Q6Q788

不含动物源

No

不含载体蛋白

No

种属

Human

复溶

Reconstitute in 200 µL of water

存储溶液

Constituents: 0.29% Sodium chloride, 0.24% Tris

storage-buffer

style
left-column

搭配使用产品

Proteins & Peptides

AB322097

Recombinant Mouse APOA1 Protein Standard (His tag)

Sandwich ELISA - Recombinant Mouse APOA1 Protein Standard (His tag) (AB322097)

  • 0
  • 0
Proteins & Peptides

AB226264

Recombinant Mouse Apolipoprotein CIII (Tagged)

SDS-PAGE - Recombinant Mouse Apolipoprotein CIII (Tagged) (AB226264)

  • 0
  • 0
Proteins & Peptides

AB280330

Recombinant human Apolipoprotein E3

Mass Spectrometry - Recombinant human Apolipoprotein E3 (AB280330)

  • 0
  • 0
Proteins & Peptides

AB114408

Recombinant Human CETP protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human CETP protein (GST tag N-Terminus) (AB114408)

  • 0
  • 0
style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
style
left-column

产品详情

This product was previously labelled as Apolipoprotein A V
style
left-column

序列信息

[{"linker":null,"sequence":"RKGFWDYFSQTSGDKGRVEQIHQQKMAREPATLKDSLEQDLNNMNKFLEKLRPLSGSEAPRLPQDPVGMRRQLQEELEEVKARLQPYMAEAHELVGWNLEGLRQQLKPYTMDLMEQVALRVQELQEQLRVVGEDTKAQLLGGVDEAWALLQGLQSRVVHHTGRFKELFHPYAESLVSGIGRHVQELHRSVAPHAPASPARLSRCVQVLSRKLTLKAKALHARIQQNLDQLREELSRAFAGTGTEEGAGPDPQMLSEEVRQRLQAFRQDTYLQIAAFTRAIDQETEEVQQQLAPPPPGHSAFAPEFQQTDSGKVLSKLQARLDDLWEDITHSLHDQGHSHLGDPAAADYKDDDDK","proteinLength":"Full Length","predictedMolecularWeight":"40.1 kDa","actualMolecularWeight":null,"aminoAcidEnd":366,"aminoAcidStart":24,"nature":"Recombinant","expressionSystem":"HEK 293 cells","accessionNumber":"Q6Q788","tags":[{"tag":"DDDDK","terminus":"C-Terminus"}]}]
style
left-column

性能和储存信息

形式
Lyophilized
运输条件
Blue Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Apolipoprotein A V also known as APOA5 plays a critical role in lipid metabolism. This protein possesses a molecular weight of approximately 39 kDa and is mainly expressed in the liver. APOA5 modulates the plasma triglyceride levels by enhancing the uptake and clearance of triglyceride-rich lipoproteins. The protein is located at the surface of these lipoproteins facilitating their interaction with receptors and enzymes like lipoprotein lipase.
Biological function summary

APOA5 influences triglyceride metabolism and is part of the HDL particle complex. It interacts directly with lipoprotein lipase to promote the hydrolysis of triglycerides into free fatty acids. This hydrolytic action aids in reducing triglyceride levels in the plasma. APOA5 also indirectly influences very-low-density lipoprotein (VLDL) metabolism reinforcing its role in lipid regulation.

Pathways

APOA5 integrates into the lipoprotein metabolic pathway and the PPAR signaling pathway. In the lipoprotein metabolic pathway APOA5 works with proteins like APOC3 to influence triglyceride homeostasis. This protein is modulated by PPAR-alpha helping control lipid metabolism and energy homeostasis. Its role in these pathways highlights its impact on triglyceride-rich lipoprotein metabolism positioning it as an important player in maintaining lipid balance.

APOA5 strongly associates with hypertriglyceridemia and cardiovascular disease. Variations in the APOA5 gene can lead to abnormal plasma triglyceride levels contributing to the development of hypertriglyceridemia. Additionally APOA5's connection with APOE proteins through lipid metabolism pathways can influence susceptibility to cardiovascular disorders. Understanding the interactions and mutations within APOA5 provides insights into the mechanisms contributing to these disease states.
style
left-column

常规信息

功能

Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin : cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin (PubMed : 17326667).

序列相似性

Belongs to the apolipoprotein A1/A4/E family.

翻译后修饰

Phosphorylated by FAM20C in the extracellular medium.

亚细胞定位

Early endosome

style
left-column

产品实验方案

style
left-column

靶点信息

Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin : cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin (PubMed : 17326667).
See full target information APOA5
style
left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Immunity 56:2523-2541.e8 PubMed37924812

2023

Gasdermin D permeabilization of mitochondrial inner and outer membranes accelerates and enhances pyroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Rui Miao,Cong Jiang,Winston Y Chang,Haiwei Zhang,Jinsu An,Felicia Ho,Pengcheng Chen,Han Zhang,Caroline Junqueira,Dulguun Amgalan,Felix G Liang,Junbing Zhang,Charles L Evavold,Iva Hafner-Bratkovič,Zhibin Zhang,Pietro Fontana,Shiyu Xia,Markus Waldeck-Weiermair,Youdong Pan,Thomas Michel,Liron Bar-Peled,Hao Wu,Jonathan C Kagan,Richard N Kitsis,Peng Zhang,Xing Liu,Judy Lieberman
View all publications
style
left-column
style
left-column
style
right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com