AB157866

重组人AP1B1蛋白

Name: 重组人AP1B1蛋白 (ab157866)| Abcam中文官网
Brand: Abcam Limited
SKU: AB157866
Price: 6878 CNY
Availability: InStock

Recombinant Human AP1B1 protein

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Recombinant Human AP1B1 protein is a Human Full Length protein, in the 1 to 939 aa range, expressed in Wheat germ, suitable for ELISA, WB.

查看别名

ADTB1, BAM22, CLAPB2, AP1B1, AP-1 complex subunit beta-1, Adaptor protein complex AP-1 subunit beta-1, Adaptor-related protein complex 1 subunit beta-1, Beta-1-adaptin, Beta-adaptin 1, Clathrin assembly protein complex 1 beta large chain, Golgi adaptor HA1/AP1 adaptin beta subunit

1 Images

SDS-PAGE - Recombinant Human AP1B1 protein (AB157866)

SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human AP1B1 protein (AB157866)

ab157866 on a 12.5% SDS-PAGE stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

应用

ELISA, WB

applications

生物活性

访问

Q10567

不含动物源

不含载体蛋白

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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序列信息

[{"sequence":"MTDSKYFTTTKKGEIFELKAELNSDKKEKKKEAVKKVIASMTVGKDVSALFPDVVNCMQTDNLELKKLVYLYLMNYAKSQPDMAIMAVNTFVKDCEDPNPLIRALAVRTMGCIRVDKITEYLCEPLRKCLKDEDPYVRKTAAVCVAKLHDINAQLVEDQGFLDTLKDLISDSNPMVVANAVAALSEIAESHPSSNLLDLNPQSINKLLTALNECTEWGQIFILDCLANYMPKDDREAQSICERVTPRLSHANSAVVLSAVKVLMKFMEMLSKDLDYYGTLLKKLAPPLVTLLSAEPELQYVALRNINLIVQKRPEILKHEMKVFFVKYNDPIYVKLEKLDIMIRLASQANIAQVLAELKEYATEVDVDFVRKAVRAIGRCAIKVEQSAERCVSTLLDLIQTKVNYVVQEAIVVIKDIFRKYPNKYESVIATLCENLDSLDEPEARAAMIWIVGEYAERIDNADELLESFLEGFHDESTQVQLQLLTAIVKLFLKKPTETQELVQQVLSLATQDSDNPDLRDRGYIYWRLLSTDPVAAKEVVLAEKPLISEETDLIEPTLLDELICYIGTLASVYHKPPSAFVEGGRGVVHKSLPPRTASSESAESPETAPTGAPPGEQPDVIPAQGDLLGDLLNLDLGPPVSGPPLATSSVQMGAVDLLGGGLDSLIGGTNFVAPPTAAVPANLGAPIGSGLSDLFDLTSGVGTLSGSYVAPKAVWLPAMKAKGLEISGTFTRQVGSISMDLQLTNKALQVMTDFAIQFNRNSFGLAPAAPLQVHAPLSPNQTVEISLPLSTVGSVMKMEPLNNLQVAVKNNIDVFYFSTLYPLHILFVEDGKMDRQMFLATWKDIPNENEAQFQIRDCPLNAEAASSKLQSSNIFTVAKRNVEGQDMLYQSLKLTNGIWVLAELRIQPGNPSCTLSLKCRAPEVSQHVYQAYETILKN","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":939,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"Q10567","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]

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性能和储存信息

运输条件

Dry Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

False

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

AP1B1 also known as Adaptor-related protein complex 1 subunit beta-1 is involved in mechanical functions related to protein sorting and vesicle formation. It has a molecular mass of approximately 105 kDa. This protein forms part of the AP-1 complex which is present in various cell types particularly expressed in epithelial tissues. AP1B1 functions as an important component in clathrin-coated vesicle transport assisting in the selection of cargo that is transported between the trans-Golgi network and endosomes.

Biological function summary

The role of the AP1B1 extends to ensuring proper cellular trafficking maintaining cell polarity and function within epithelial cells. As part of the AP-1 complex it interacts with other subunits to facilitate the budding of vesicles a critical step in cell function and homeostasis. AP1B1's involvement in intracellular transport underlines its significance in cellular processes that require precise protein localization and distribution.

Pathways

The AP1B1 protein plays an essential role in the clathrin-mediated endocytosis and post-Golgi trafficking pathways. It operates alongside other proteins like clathrin and AP-1 γ subunit coordinating the transport of receptors and other protein complexes to their specific intracellular destinations. This molecular coordination supports processes such as receptor recycling and lysosomal targeting within the cell environment.

Errors in AP1B1 function can link to specific medical conditions such as Hermansky-Pudlak syndrome and neurodegenerative diseases. In these conditions alterations in the AP1B1 protein may disrupt normal vesicle trafficking and protein sorting processes. The disorder-related disruption illustrates how AP1B1 potentially interacting with proteins like the lysosomal-associated membrane protein 2 can impact cellular homeostasis and lead to systemic effects in tissue biology.

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特殊说明

形式

Liquid

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常规信息

功能

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes (PubMed : 31630791). The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.

序列相似性

Belongs to the adaptor complexes large subunit family.

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产品实验方案

Visit the General protocols
Visit the Troubleshooting

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靶点信息

See full target information AP1B1

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重组人AP1B1蛋白

Recombinant Human AP1B1 protein

SDS-PAGE - Recombinant Human AP1B1 protein (AB157866)

关键信息

表达系统

标签

应用

生物活性

访问

不含动物源

不含载体蛋白

种属

存储溶液