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AB92934

重组人 Annexin-6/ANXA6 蛋白 (His tag N-Terminus)

Recombinant Human Annexin-6/ANXA6 protein (His tag N-Terminus)

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(1 Publication)

Recombinant Human Annexin-6/ANXA6 protein (His tag N-Terminus) is a Human Full Length protein, in the 1 to 673 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.

查看别名

ANX6, ANXA6, Annexin A6, 67 kDa calelectrin, Annexin VI, Annexin-6, Calphobindin-II, Chromobindin-20, Lipocortin VI, Protein III, p68, p70, CPB-II

1 Images
SDS-PAGE - Recombinant Human Annexin-6/ANXA6 protein (His tag N-Terminus) (AB92934)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Annexin-6/ANXA6 protein (His tag N-Terminus) (AB92934)

15% SDS-PAGE showing ab92934 (Annexin-6/ANXA6 protein) at approximately 78 kDa (3 μg).

关键信息

纯度

>90% SDS-PAGE

ab92934 is purified using conventional chromatography techniques.

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

P08133

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl

storage-buffer

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搭配使用产品

Reagents, Controls & Accessories

AB133411

Low Fluorescence Western Membrane (PVDF)

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  • 1
Proteins & Peptides

AB317875

Recombinant Human ANXA1 Protein (His-tag)

Mass Spectrometry - Recombinant Human ANXA1 Protein (His-tag) (AB317875)

  • 0
  • 0
Proteins & Peptides

AB255714

Recombinant Human Annexin V/ANXA5 protein

SDS-PAGE - Recombinant Human Annexin V/ANXA5 protein (AB255714)

  • 0
  • 0
Proteins & Peptides

AB93005

Recombinant Human Annexin-2/ANXA2 protein (6x His tag N-Terminus)

Western blot - Recombinant Human Annexin-2/ANXA2 protein (6x His tag N-Terminus) (AB93005)

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  • 2
Primary Antibodies

AB199422

Anti-Annexin-6/ANXA6 antibody [EPR17308] - N-terminal

RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-Annexin-6/ANXA6 antibody [EPR17308] - N-terminal (AB199422)

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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产品详情

This product was previously labelled as Annexin VI
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序列信息

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMAKPAQGAKYRGSIHDFPGFDPNQDAEALYTAMKGFGSDKEAILDIITSRSNRQRQEVCQSYKSLYGKDLIADLKYELTGKFERLIVGLMRPPAYCDAKEIKDAISGIGTDEKCLIEILASRTNEQMHQLVAAYKDAYERDLEADIIGDTSGHFQKMLVVLLQGTREEDDVVSEDLVQQDVQDLYEAGELKWGTDEAQFIYILGNRSKQHLRLVFDEYLKTTGKPIEASIRGELSGDFEKLMLAVVKCIRSTPEYFAERLFKAMKGLGTRDNTLIRIMVSRSELDMLDIREIFRTKYEKSLYSMIKNDTSGEYKKTLLKLSGGDDDAAGQFFPEAAQVAYQMWELSAVARVELKGTVRPANDFNPDADAKALRKAMKGLGTDEDTIIDIITHRSNVQRQQIRQTFKSHFGRDLMTDLKSEISGDLARLILGLMMPPAHYDAKQLKKAMEGAGTDEKALIEILATRTNAEIRAINEAYKEDYHKSLEDALSSDTSGHFRRILISLATGHREEGGENLDQAREDAQVAAEILEIADTPSGDKTSLETRFMTILCTRSYPHLRRVFQEFIKMTNYDVEHTIKKEMSGDVRDAFVAIVQSVKNKPLFFADKLYKSMKGAGTDEKTLTRIMVSRSEIDLLNIRREFIEKYDKSLHQAIEGDTSGDFLKALLALCGGED","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":673,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"P08133","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

形式
Liquid
运输条件
Blue Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Annexin-6 also known as ANXA6 is a member of the annexin family of proteins. It has a mass of approximately 68 kDa and is expressed in various tissues with substantial presence in muscle and liver. This protein acts mechanically by binding to membranes in a calcium-dependent manner playing a role in membrane-associated processes such as endocytosis and exocytosis. Annexin-6 can also interact with cytoskeletal elements influencing cell structure and stability.
Biological function summary

Annexin-6 functions as a versatile scaffold that organizes multiprotein complexes. It modulates membrane trafficking processes and participates in signaling pathways within the cell. This protein can influence intracellular calcium homeostasis by interacting with calcium channels and transporters making it an integral part of cellular signaling and communication.

Pathways

Annexin-6 plays a role in the MAPK and PI3K/Akt signaling pathways. It associates with proteins such as Ras and Protein Kinase C impacting cell proliferation survival and differentiation. These interactions highlight the importance of annexin-6 in cellular responses to external stimuli and help regulate various physiological processes in the body.

Annexin-6 has been linked to cardiac disorders and cancer. In the context of cardiac health it interacts with proteins like phospholamban and calmodulin to influence heart muscle function and calcium regulation. In cancer annexin-6's involvement in the Akt signaling pathway can affect tumor growth and metastasis often interacting with other proteins like EGFR and HER2. This makes it a significant protein of interest in disease research and potential therapeutic targeting.
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常规信息

功能

May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.

序列相似性

Belongs to the annexin family.

翻译后修饰

Phosphorylated in response to growth factor stimulation.

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产品实验方案

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靶点信息

May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.
See full target information ANXA6
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

eLife 9: PubMed32420875

2020

ER-luminal [Ca] regulation of InsP receptor gating mediated by an ER-luminal peripheral Ca-binding protein.

Applications

Unspecified application

Species

Unspecified reactive species

Horia Vais,Min Wang,Karthik Mallilankaraman,Riley Payne,Chris McKennan,Jeffrey T Lock,Lynn A Spruce,Carly Fiest,Matthew Yan-Lok Chan,Ian Parker,Steven H Seeholzer,J Kevin Foskett,Don-On Daniel Mak
View all publications
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