重组人 alpha smooth muscle Actin 蛋白 (His tag N-Terminus)
Recombinant Human alpha smooth muscle Actin protein (His tag N-Terminus)
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(1 Publication)
Recombinant Human alpha smooth muscle Actin protein (His tag N-Terminus) is a Human Full Length protein, in the 3 to 377 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE, Mass Spec.
查看别名
ACTSA, ACTVS, GIG46, ACTA2, Alpha-actin-2, Cell growth-inhibiting gene 46 protein
- SDS-PAGE
Unknown
SDS-PAGE - Recombinant Human alpha smooth muscle Actin protein (His tag N-Terminus) (AB134555)
15% SDS-PAGE analysis of 3 µg ab134555.
搭配使用产品
Reagents, Controls & Accessories
AB325994
Prestained Protein Ladder - Mid-range molecular weight (11-180 kDa, 4-color)
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反应性数据
序列信息
性能和储存信息
形式
运输条件
推荐的短期储存时间
推荐的短期储存条件
推荐的长期储存条件
分装信息
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Alpha smooth muscle actin aids in maintaining the structural integrity of tissues by forming part of the actin cytoskeleton an important element in cellular support. It exists in high concentration in stress fibers contributing to cellular movements and shape maintenance. These actions are essential in various dynamic cellular processes such as cell migration and adhesion. Alpha smooth muscle actin does not typically form complexes but it associates with other components of the actin cytoskeleton to ensure cell stability and function.
Pathways
Alpha smooth muscle actin functions significantly within the TGF-beta signaling pathway which influences cell proliferation differentiation and apoptosis. It interacts closely with proteins such as myosin to facilitate cellular contractility and motility. Additionally α-SMA plays a part in the RhoA/Rho kinase (ROCK) pathway connecting with regulators of actin filament organization. These pathways are essential for modulation of smooth muscle contraction and actin filament assembly contributing to vascular development and wound healing.
常规信息
功能
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
序列相似性
Belongs to the actin family.
翻译后修饰
Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization.. Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration.. Methylated at His-75 by SETD3.. Actin, aortic smooth muscle, intermediate form. N-terminal cleavage of acetylated cysteine of intermediate muscle actin by ACTMAP.. (Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-52 of one monomer and Glu-272 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding (PubMed:19015515). The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners (PubMed:26228148).
亚细胞定位
Cytoskeleton
靶点信息
文献 (1)
Recent publications for all applications. Explore the full list and refine your search
eLife 7: PubMed30260317
2018
Applications
Unspecified application
Species
Unspecified reactive species
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