重组人Alpha B Crystallin蛋白(ab48779)
Key features and details
- Expression system: Escherichia coli
- Purity: > 95% SDS-PAGE
- Suitable for: SDS-PAGE, WB
描述
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产品名称
重组人Alpha B Crystallin蛋白
参阅全部 Alpha B Crystallin 蛋白酶 -
纯度
> 95 % SDS-PAGE. -
表达系统
Escherichia coli -
蛋白长度
Full length protein -
无动物成分
No -
性质
Recombinant -
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种属
Human -
序列
MDIAIHHPWI RRPFFPFHSP SRLFDQFFGE HLLESDLFPT STSLSPFYLR PPSFLRAPSW FDTGLSEMRL EKDRFSVNLD VKHFSPEELK VKVLGDVIEV HGKHEERQDE HGFISREFHR KYRIPADVDP LTITSSLSSD GVLTVNGPRK QVSGPERTIP ITREEKPAVT AAPKK -
预测分子量
20 kDa -
氨基酸
1 to 175
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相关产品
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Related Products
技术指标
Our Abpromise guarantee covers the use of ab48779 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
SDS-PAGE
Western blot
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形式
Liquid -
Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
pH: 7.50
Constituents: 0.316% Tris HCl, 0.0292% EDTA, 0.29% Sodium chloride
常规信息
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别名
- AACRYA
- Alpha B crystallin
- Alpha crystallin B chain
see all -
功能
May contribute to the transparency and refractive index of the lens. -
组织特异性
Lens as well as other tissues. -
疾病相关
Defects in CRYAB are the cause of myofibrillar alpha-B crystallin-related (MFM-CRYAB) [MIM:608810]. A neuromuscular disorder that results in weakness of the proximal and distal limb muscles, weakness of the neck, velopharynx and trunk muscles, hypetrophic cardiomyopathy, and cataract in a subset of patients. -
序列相似性
Belongs to the small heat shock protein (HSP20) family. -
细胞定位
Cytoplasm. Nucleus. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. - Information by UniProt
图片
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SDS-PAGE - Recombinant Human Alpha B Crystallin protein (ab48779)14% SDS-PAGE gel loaded with ab48779,
recombinant Human alpha B Crystallin,
predicted molecular weight 20.1 kDa -
Western blot - Recombinant Human Alpha B Crystallin protein (ab48779)
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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Datasheet download
文献 (4)
ab48779 被引用在 4 文献中.
- Eschbach J et al. Drug upgrade: A complete methodology from old drug to new chemical entities using Nematic Protein Organization Technique. Drug Dev Res 85:e22151 (2024). PubMed: 38349254
- Waddingham MT et al. Geranylgeranylacetone reduces cardiomyocyte stiffness and attenuates diastolic dysfunction in a rat model of cardiometabolic syndrome. Physiol Rep 11:e15788 (2023). PubMed: 37985159
- Kötter S et al. Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins. J Cell Biol 204:187-202 (2014). PubMed: 24421331
- Rao NA et al. Small Heat Shock Protein aA-Crystallin Prevents Photoreceptor Degeneration in Experimental Autoimmune Uveitis. PLoS One 7:e33582 (2012). PubMed: 22479415
