重组人Adipose Triglyceride Lipase蛋白(His tag)
Recombinant Human Adipose Triglyceride Lipase protein (His tag)
Be the first to review this product! Submit a review
|
(0 Publication)
Recombinant Human Adipose Triglyceride Lipase protein (His tag) is a Human Full Length protein, in the 1 to 504 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE.
查看别名
ATGL, FP17548, PNPLA2, Patatin-like phospholipase domain-containing protein 2, Adipose triglyceride lipase, Calcium-independent phospholipase A2-zeta, Desnutrin, Pigment epithelium-derived factor receptor, TTS2.2, Transport-secretion protein 2, iPLA2-zeta, PEDF-R, TTS2
- SDS-PAGE
Supplier Data
SDS-PAGE - Recombinant Human Adipose Triglyceride Lipase protein (His tag) (AB226233)
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) analysis of ab226233 with 5% enrichment gel and 15% separation gel.
反应性数据
序列信息
性能和储存信息
运输条件
推荐的短期储存条件
推荐的长期储存条件
分装信息
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
ATGL is part of the lipid mobilization process and contributes significantly to energy homeostasis. It acts distinctively as it breaks down phosphotriglycerides and is not part of a larger complex carrying out its function independently. Its activity impacts the balance of lipid storage and release important for maintaining energy levels within cells and across the entire organism.
Pathways
ATGL plays a significant role in the lipid catabolism and energy regulation pathways. ATGL's activity regulates the fat mobilization pathway by interacting closely with the protein Comparative Gene Identification-58 (CGI-58) which activates it. Further ATGL is involved in the peroxisome proliferator-activated receptor (PPAR) pathway highlighting its role in influencing metabolic processes and energy balance.
特殊说明
形式
Liquid
常规信息
功能
Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed : 15364929, PubMed : 15550674, PubMed : 16150821, PubMed : 16239926, PubMed : 17603008, PubMed : 34903883). Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone and acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade (By similarity). Also possesses acylglycerol transacylase and phospholipase A2 activities (PubMed : 15364929, PubMed : 17032652, PubMed : 17603008). Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides (PubMed : 17603008). Regulates adiposome size and may be involved in the degradation of adiposomes (PubMed : 16239926). Catalyzes the formation of an ester bond between hydroxy fatty acids and fatty acids derived from triglycerides or diglycerides to generate fatty acid esters of hydroxy fatty acids (FAHFAs) in adipocytes (PubMed : 35676490). Acts antagonistically with LDAH in regulation of cellular lipid stores (PubMed : 28578400). Inhibits LDAH-stimulated lipid droplet fusion (PubMed : 28578400). May play an important role in energy homeostasis (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (By similarity).
翻译后修饰
Phosphorylation at Ser-404 by PKA is increased during fasting and moderate intensity exercise, and moderately increases lipolytic activity (By similarity). Phosphorylation at Ser-404 is increased upon beta-adrenergic stimulation (PubMed:22733971).. Ubiquitinated by PEX2 in response to reactive oxygen species (ROS), leading to its degradation (PubMed:34903883). Ubiquitination is stimulated by LDAH (PubMed:28578400).
靶点信息
搭配使用产品
Abcam Product Promise
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com