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AB157832

重组人Acrosin蛋白

Recombinant Human Acrosin protein

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Recombinant Human Acrosin protein is a Human Full Length protein, in the 1 to 421 aa range, expressed in Wheat germ, suitable for ELISA, WB.

查看别名

ACRS, ACR, Acrosin

1 Images
SDS-PAGE - Recombinant Human Acrosin protein (AB157832)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human Acrosin protein (AB157832)

ab157832 on a 12.5% SDS-PAGE stained with Coomassie Blue.

关键信息

表达系统

Wheat germ

标签

GST tag N-Terminus

应用

ELISA, WB

applications

生物活性

No

访问

P10323

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"MVEMLPTAILLVLAVSVVAKDNATCDGPCGLRFRQNPQGGVRIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRLVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPYLNWIASKIGSNALRMIQSATPPPPTTRPPPIRPPFSHPISAHLPWYFQPPPRPLPPRPPAAQPRPPPSPPPPPPPPASPLPPPPPPPPPTPSSTTKLPQGLSFAKRLQQLIEVLKGKTYSDGKNHYDMETTELPELTSTS","proteinLength":"Full Length","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":421,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P10323","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Acrosin also known as ZPC and with a mass of approximately 40 kDa acts as a proteolytic enzyme in sperm cells. It falls under the category of serine proteases. Acrosin is synthesized in the acrosome of spermatozoa and gets activated during the sperm's travel through the female reproductive tract. The enzyme's main mechanical function is to digest the zona pellucida the outer glycoprotein layer of the egg aiding in sperm penetration and fertilization process.
Biological function summary

Enzymes like acrosin play significant roles in fertilization. Acrosin remains stored as proacrosin its inactive zymogen form within the acrosome until it is activated. This protein operates as part of a complex network that includes other acrosomal proteins. The activation of acrosin is tightly controlled ensuring the precise timing and localization of its enzymatic activity required for efficient sperm-egg fusion.

Pathways

Sperm motility and capacitation pathways integrate acrosin activity. These pathways are pivotal during fertilization as they govern the sperm's ability to reach and penetrate the egg. Acrosin interacts with enzymes like hyaluronidase in pathways where the digestion of the zona pellucida is necessary. This interaction ensures that sperm cells effectively breach the barriers surrounding the oocyte for successful fertilization.

Fertilization problems can connect with acrosin function anomalies. Improper activation or deficits in acrosin activity may contribute to infertility. Additionally anomalies in related proteins such as other serine proteases or those within the sperm's acrosome can lead to unsuccessful sperm-egg interactions. Research focuses on exploring these relationships to identify potential diagnostic markers or therapeutic targets for addressing infertility issues associated with acrosomal proteins like acrosin.
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特殊说明

形式

Liquid

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常规信息

功能

Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.

序列相似性

Belongs to the peptidase S1 family.

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产品实验方案

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靶点信息

Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.
See full target information ACR
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