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AB181894

重组人 ABHD12B 蛋白 (denatured) (His tag N-Terminus)

Recombinant Human ABHD12B protein (denatured) (His tag N-Terminus)

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Recombinant Human ABHD12B protein (denatured) (His tag N-Terminus) is a Human Full Length protein, in the 1 to 255 aa range, expressed in Escherichia coli, with >85%, suitable for SDS-PAGE.

查看别名

C14orf29, ABHD12B, Protein ABHD12B, Abhydrolase domain-containing protein 12B, Alpha/beta hydrolase domain-containing protein 12B

1 Images
SDS-PAGE - Recombinant Human ABHD12B protein (denatured) (His tag N-Terminus) (AB181894)
  • SDS-PAGE

Supplier Data

SDS-PAGE - Recombinant Human ABHD12B protein (denatured) (His tag N-Terminus) (AB181894)

SDS-PAGE analysis of Recombinant Human ABHD12B protein (ab181894), under reducing conditions. Proteins visualized by coomassie blue stain.

Lane 1 : Molecular Weight Standards

Lane 2 : 3 μg Recombinant Human ABHD12B protein

关键信息

纯度

>85% SDS-PAGE

表达系统

Escherichia coli

标签

His tag N-Terminus

应用

SDS-PAGE

applications

生物活性

No

访问

Q7Z5M8

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 10% Glycerol (glycerin, glycerine), 2.4% Urea, 0.32% Tris HCl

storage-buffer

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搭配使用产品

Proteins & Peptides

AB126655

Recombinant Human ABHD10 protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human ABHD10 protein (His tag N-Terminus) (AB126655)

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Primary Antibodies

AB179515

Anti-pro Caspase-1 + p10 + p12 antibody [EPR16883]

RabMAb|Recombinant|20ul selling size

Western blot - Anti-pro Caspase-1 + p10 + p12 antibody [EPR16883] (AB179515)

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Proteins & Peptides

AB164800

Recombinant Human TMEM116 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human TMEM116 protein (GST tag N-Terminus) (AB164800)

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Proteins & Peptides

AB276749

Recombinant Mouse Frizzled 2/FZD2 protein (Fc Chimera)

SDS-PAGE - Recombinant Mouse Frizzled 2/FZD2 protein (Fc Chimera) (AB276749)

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "SDS-PAGE": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"linker":null,"sequence":"MGSSHHHHHHSSGLVPRGSHMGSMLGIWHTVPSCRGEDAKGKDCCWYEAALRDGNPIIVYLHGSAEHRAASHRLKLVKVLSDGGFHVLSVDYRGFGDSTGKPTEEGLTTDAICVYEWTKARSGITPVCLWGHSLGTGVATNAAKVLEEKGCPVDAIVLEAPFTNMWVASINYPLLKIYRNIPGFLRTLMDALRKDKIIFPNDENVKFLSSPLLILHGEDDRTVPLEYGKKLYEIARNAYRNKERVKMVIFPPGFQHNLLCKSPTLLITVRDFLSKQWS","proteinLength":"Full Length","predictedMolecularWeight":"31 kDa","actualMolecularWeight":null,"aminoAcidEnd":255,"aminoAcidStart":1,"nature":"Recombinant","expressionSystem":"Escherichia coli","accessionNumber":"Q7Z5M8","tags":[{"tag":"His","terminus":"N-Terminus"}]}]
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性能和储存信息

形式
Liquid
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ABHD12B known as alpha/beta hydrolase domain-containing protein 12B functions mechanically as a hydrolytic enzyme. It participates in lipid metabolism by breaking down specific substrates through its hydrolase activity. The target has a molecular mass of approximately 45 kDa. Expression of ABHD12B occurs in various tissues with noted presence in the brain and other organs involved in lipid regulation.
Biological function summary

ABHD12B contributes to the regulation of lipid signaling pathways. This enzyme plays a role in maintaining lipid homeostasis impacting signaling molecules like lysophosphatidylserines. ABHD12B does not function alone; it may interact with other proteins within a larger enzymatic complex. This interaction influences cellular processes by modifying bioactive lipids that serve as signaling messengers.

Pathways

ABHD12B participates in the endocannabinoid signaling pathway and the phosphatidylserine metabolism pathway. These pathways are critical in cellular communication and homeostatic balance. In these pathways ABHD12B collaborates with proteins like phospholipase A2 and cannabinoid receptors. Its actions influence the concentration of lipid-derived signals that modulate receptor activity and cellular responses.

ABHD12B has potential connections to neurodegenerative diseases and metabolic disorders. Dysregulation of its activity might lead to abnormal lipid accumulation or signaling disruption underlying disorders such as neurodegeneration. The target shows functional linkage to proteins implicated in these conditions such as ABHD12 and presenilin suggesting a role in the pathological progression of these disorders. Understanding ABHD12B's involvement in these diseases offers potential therapeutic avenues targeting lipid metabolic pathways.
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常规信息

序列相似性

Belongs to the serine esterase family.

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产品实验方案

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靶点信息

See full target information ABHD12B
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