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AB112316

重组人 67kDa Laminin Receptor 蛋白 (GST tag N-Terminus)

Recombinant Human 67kDa Laminin Receptor protein (GST tag N-Terminus)

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(1 Publication)

Recombinant Human 67kDa Laminin Receptor protein (GST tag N-Terminus) is a Human Fragment protein, in the 196 to 295 aa range, expressed in Wheat germ, suitable for ELISA, WB.

查看别名

LAMBR, LAMR1, RPSA, Small ribosomal subunit protein uS2, 37 kDa laminin receptor precursor, 37/67 kDa laminin receptor, 40S ribosomal protein SA, 67 kDa laminin receptor, Colon carcinoma laminin-binding protein, Laminin receptor 1, Laminin-binding protein precursor p40, Multidrug resistance-associated protein MGr1-Ag, NEM/1CHD4, 37LRP, LRP/LR, 67LR, LamR, LBP/p40

1 Images
SDS-PAGE - Recombinant Human 67kDa Laminin Receptor protein (GST tag N-Terminus) (AB112316)
  • SDS-PAGE

Unknown

SDS-PAGE - Recombinant Human 67kDa Laminin Receptor protein (GST tag N-Terminus) (AB112316)

ab112316 on a 12.5% SDS-PAGE Stained with Coomassie Blue

关键信息

表达系统

Wheat germ

标签

GST tag N-Terminus

应用

WB, ELISA

applications

生物活性

No

访问

P08865

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 8 Constituents: 0.79% Tris HCl, 0.31% Glutathione

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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序列信息

[{"sequence":"EVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTATQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTDWS","proteinLength":"Fragment","predictedMolecularWeight":"36.63 kDa","actualMolecularWeight":null,"aminoAcidEnd":295,"aminoAcidStart":196,"nature":"Recombinant","expressionSystem":"Wheat germ","accessionNumber":"P08865","tags":[{"tag":"GST","terminus":"N-Terminus"}]}]
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性能和储存信息

运输条件
Dry Ice
推荐的短期储存条件
-80°C
推荐的长期储存条件
-80°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The 67kDa Laminin Receptor also known as the laminin binding protein or protein laminin functions as a receptor for laminin an important component of the extracellular matrix. This receptor is expressed in many tissue types serving an important mechanical role by mediating the adhesion and migration of cells. The receptor anchors cells to laminin molecules thereby influencing cell differentiation and proliferation. The molecular weight of the laminin receptor is approximately 67 kilodaltons which signifies it as a critical player in various cellular processes.
Biological function summary

This receptor engages in cellular interactions that are essential for maintaining the integrity and architecture of tissues. It often associates with other proteins to form complexes which further strengthen its functional capabilities. By anchoring laminin to the cell surface it regulates cell signaling pathways that influence cell motility invasion and survival. These interactions suggest that the 67kDa Laminin Receptor's function goes beyond simple adhesion impacting cellular responsiveness to external matrix cues.

Pathways

The receptor influences the MAPK and PI3K/Akt signaling pathways which are significant in cell survival and proliferation. Through such pathways it interacts with numerous proteins including integrins and fibronectin receptors facilitating orchestrated cell signaling. This connectivity highlights the receptor's role in cellular communication networks contributing to dynamic processes like wound healing and angiogenesis.

Aberrant expression of the 67kDa Laminin Receptor relates to conditions such as cancer and Alzheimer's disease. In cancer its overexpression links to increased tumor invasiveness likely due to enhanced cell motility mediated through integrin interactions. In Alzheimer's disease its relationship with amyloid precursor protein influences plaque formation exacerbating disease progression. Understanding these connections highlights potential therapeutic targets for disease intervention.
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特殊说明

形式

Liquid

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常规信息

功能

Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA.. (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9.. (Microbial infection) Acts as a receptor for the Dengue virus.. (Microbial infection) Acts as a receptor for the Sindbis virus.. (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus.. (Microbial infection) Acts as a receptor for the pathogenic prion protein.. (Microbial infection) Acts as a receptor for bacteria.

序列相似性

Belongs to the universal ribosomal protein uS2 family.

翻译后修饰

Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association (PubMed:9581863).. Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.

亚细胞定位

Nucleus

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产品实验方案

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靶点信息

Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA.. (Microbial infection) Acts as a receptor for the Adeno-associated viruses 2,3,8 and 9.. (Microbial infection) Acts as a receptor for the Dengue virus.. (Microbial infection) Acts as a receptor for the Sindbis virus.. (Microbial infection) Acts as a receptor for the Venezuelan equine encephalitis virus.. (Microbial infection) Acts as a receptor for the pathogenic prion protein.. (Microbial infection) Acts as a receptor for bacteria.
See full target information RPSA
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Cancer biology & therapy 16:724-32 PubMed25799942

2015

Monoclonal antibodies specific for oncofetal antigen--immature laminin receptor protein: Effects on tumor growth and spread in two murine models.

Applications

Unspecified application

Species

Unspecified reactive species

Shannon D McClintock,Roscoe L Warner,Saqib Ali,Apurupa Chekuri,Michael K Dame,Durga Attili,Randall K Knibbs,Muhammad Nadeem Aslam,Joseph Sinkule,Alton Charles Morgan,Adel Barsoum,Lauren B Smith,David G Beer,Kent J Johnson,James Varani
View all publications
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搭配使用产品

Reagents, Controls & Accessories

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Primary Antibodies

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Proteins & Peptides

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Primary Antibodies

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