AB43040

重组Cytomegalovirus Glycoprotein B

Name: 重组Cytomegalovirus Glycoprotein B (ab43040)| Abcam中文官网
Brand: Abcam Limited
SKU: AB43040
Price: 2983 CNY
Availability: InStock

Recombinant Cytomegalovirus Glycoprotein B

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(6 Publications)

Recombinant Cytomegalovirus Glycoprotein B is a Human herpesvirus 5 strain AD169 Fragment protein, expressed in Escherichia coli, with >95%, suitable for ELISA, WB.

查看别名

UL55, gB, Envelope glycoprotein B

关键信息

纯度

>95% SDS-PAGE

表达系统

Escherichia coli

应用

ELISA, WB

applications

生物活性

访问

P06473

不含动物源

不含载体蛋白

种属

Human herpesvirus 5 strain AD169

存储溶液

pH: 7.2 Constituents: 50% Glycerol (glycerin, glycerine), 0.395% Tris HCl, 0.0292% EDTA

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }

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序列信息

[{"sequence":"","proteinLength":"Fragment","predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Recombinant","expressionSystem":null,"accessionNumber":"P06473","tags":[]}]

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性能和储存信息

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

False

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特殊说明

形式

Liquid

附加说明

Sepharose derived purification.

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常规信息

功能

Envelope glycoprotein that plays a role in host cell entry, cell to-cell virus transmission, and fusion of infected cells. May be involved in the initial attachment via binding to heparan sulfate together with the gM/gN complex that binds heparin with higher affinity. Interacts with host integrin ITGB1, PDGFRA and EGFR that likely serve as postattachment entry receptors. Also participates in the fusion of viral and cellular membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.

序列相似性

Belongs to the herpesviridae glycoprotein B family.

翻译后修饰

A proteolytic cleavage by host furin generates two subunits that remain linked by disulfide bonds.

亚细胞定位

Host endosome membrane

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产品实验方案

Visit the General protocols
Visit the Troubleshooting

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靶点信息

See full target information gB

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文献 (6)

Recent publications for all applications. Explore the full list and refine your search

Cell 186:1417-1431.e20 PubMed37001502

2023

Cytotoxic CD4 T cells eliminate senescent cells by targeting cytomegalovirus antigen.

Applications

Unspecified application

Species

Unspecified reactive species

Tatsuya Hasegawa,Tomonori Oka,Heehwa G Son,Valeria S Oliver-García,Marjan Azin,Thomas M Eisenhaure,David J Lieb,Nir Hacohen,Shadmehr Demehri

Nature communications 14:1041 PubMed36823200

2023

The cytomegalovirus gB/MF59 vaccine candidate induces antibodies against an antigenic domain controlling cell-to-cell spread.

Applications

Unspecified application

Species

Unspecified reactive species

A C Gomes,I A Baraniak,A Lankina,Z Moulder,P Holenya,C Atkinson,G Tang,T Mahungu,F Kern,P D Griffiths,M B Reeves

Frontiers in immunology 13:1083230 PubMed36591233

2022

HCMV carriage in the elderly diminishes anti-viral functionality of the adaptive immune response resulting in virus replication at peripheral sites.

Applications

Unspecified application

Species

Unspecified reactive species

Emma L Davies,Mahlaqua Noor,Eleanor Y Lim,Charlotte J Houldcroft,Georgina Okecha,Claire Atkinson,Matthew B Reeves,Sarah E Jackson,Mark R Wills

PLoS pathogens 15:e1008064 PubMed31841557

2019

IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody.

Applications

Unspecified application

Species

Unspecified reactive species

Simone I Richardson,Bronwen E Lambson,Andrew R Crowley,Arman Bashirova,Cathrine Scheepers,Nigel Garrett,Salim Abdool Karim,Nonhlanhla N Mkhize,Mary Carrington,Margaret E Ackerman,Penny L Moore,Lynn Morris

Journal of pharmaceutical and biomedical analysis 156:372-378 PubMed29758495

2018

A rapid magnetic particle-based enzyme immunoassay for human cytomegalovirus glycoprotein B quantification.

Applications

Unspecified application

Species

Unspecified reactive species

F Pires,M Julia Arcos-Martinez,A Cristina Dias-Cabral,Juan C Vidal,Juan R Castillo

Scientific reports 7:937 PubMed28428537

2017

Human Cytomegalovirus Induces Cellular and Humoral Virus-specific Immune Responses in Humanized BLT Mice.

Applications

ELISA

Species

Unspecified reactive species

Lindsey B Crawford,Rebecca Tempel,Daniel N Streblow,Craig Kreklywich,Patricia Smith,Louis J Picker,Jay A Nelson,Patrizia Caposio

View all publications

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重组Cytomegalovirus Glycoprotein B

Recombinant Cytomegalovirus Glycoprotein B

关键信息

纯度

表达系统

标签

应用

生物活性

访问

不含动物源

不含载体蛋白

种属

存储溶液