Anti-TRAF1抗体(ab203316)
Key features and details
- Rabbit polyclonal to TRAF1
- Suitable for: IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
概述
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产品名称
Anti-TRAF1抗体
参阅全部 TRAF1 一抗 -
描述
兔多克隆抗体to TRAF1 -
宿主
Rabbit -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Mouse, Human -
免疫原
Synthetic peptide within Human TRAF1 aa 350 to the C-terminus conjugated to keyhole limpet haemocyanin. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: Q13077 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.40
Preservative: 0.02% Proclin 300
Constituents: 50% Glycerol (glycerin, glycerine), 1% BSA, 48.98% TBS, 1X -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab203316于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
1/100 - 1/500.
When using a fluorescent probe the recommended dilution is 1/50 – 1/200. |
说明 |
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IHC-P
1/100 - 1/500. When using a fluorescent probe the recommended dilution is 1/50 – 1/200. |
靶标
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功能
Adapter molecule that regulates the activation of NF-kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein-ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. -
序列相似性
Contains 1 MATH domain. -
结构域
The coiled coil domain mediates homo- and hetero-oligomerization.
The MATH/TRAF domain binds to receptor cytoplasmic domains.
Cleavage by CASP8 liberates a C-terminal fragment that promotes apoptosis and inhibits the activation of NF-kappa-B in response to TNF signaling. -
翻译后修饰
Polyubiquitinated by BIRC2 and/or BIRC3, leading to its subsequent proteasomal degradation. - Information by UniProt
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数据库链接
- Entrez Gene: 7185 Human
- Entrez Gene: 22029 Mouse
- Omim: 601711 Human
- SwissProt: Q13077 Human
- SwissProt: P39428 Mouse
- Unigene: 531251 Human
- Unigene: 239514 Mouse
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别名
- 4732496E14Rik antibody
- EBI6 antibody
- EBV induced protein 6 antibody
see all
图片
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Immunohistochemical analysis of formalin-fixed, paraffin-embedded Mouse tumor tissue labeling TRAF1 with ab203316 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.
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Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human gastric carcinoma tissue labeling TRAF1 with ab203316 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.
数据表及文件
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SDS download
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Datasheet download
文献 (1)
ab203316 被引用在 1 文献中.
- Xiao K et al. HuR Affects Proliferation and Apoptosis of Chronic Lymphocytic Leukemia Cells via NF-?B Pathway. Biomed Res Int 2020:1481572 (2020). PubMed: 32908868