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AB4978

NFAT5多肽

NFAT5 peptide

4

(1 Review)

|

(0 Publication)

NFAT5 peptide is a blocking peptide. >70% and suitable for BL.

查看别名

KIAA0827, TONEBP, NFAT5, Nuclear factor of activated T-cells 5, NF-AT5, T-cell transcription factor NFAT5, Tonicity-responsive enhancer-binding protein, TonE-binding protein, TonEBP

关键信息

纯度

>70% HPLC

标签

Tag free

应用

BL

applications

生物活性

No

访问

O94916

不含动物源

No

不含载体蛋白

No

种属

Human

复溶

Reconstitute in 0.1 mL of water

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "BL": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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产品详情

This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human NFAT5, ab3446. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (~ 70-fold) for competitive inhibition of antibody-protein binding reactions.
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
储存信息
Avoid freeze / thaw cycle
False
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特殊说明

形式

Lyophilized

附加说明

Peptides are analyzed by Reverse-Phase HPLC (RP-HPLC) in order to determine purity. Identities are confirmed by MALDI-MS.

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常规信息

功能

Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed : 10377394). Mediates the transcriptional response to hypertonicity (PubMed : 10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed : 22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA : RNA hybrid and the associated non-template single-stranded DNA (PubMed : 34049076).

翻译后修饰

Phosphorylated (PubMed:10377394). Phosphorylated at Thr-135 by CDK5 in response to osmotic stress; this phosphorylation mediates its rapid nuclear localization (PubMed:21209322).. Poly-ADP-ribosylated by PARP1 in response to DNA damage, promoting recruitment to sites of R-loop-associated DNA damage.

亚细胞定位

Nucleus

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产品实验方案

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靶点信息

Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3' (PubMed : 10377394). Mediates the transcriptional response to hypertonicity (PubMed : 10051678). Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17 (PubMed : 22266867). Also involved in the DNA damage response by preventing formation of R-loops; R-loops are composed of a DNA : RNA hybrid and the associated non-template single-stranded DNA (PubMed : 34049076).
See full target information NFAT5
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Complementary Products

Primary Antibodies

AB3446

Anti-NFAT5 antibody

Immunoprecipitation - Anti-NFAT5 antibody (AB3446)

  • 4
  • 1
Proteins & Peptides

AB112396

Recombinant Human NFAT5 protein

SDS-PAGE - Recombinant Human NFAT5 protein (AB112396)

  • 0
  • 0
Cell Lines & Lysates

AB94270

NFAT5 overexpression 293T lysate (whole cell)

Western blot - NFAT5 overexpression 293T lysate (whole cell) (AB94270)

  • 0
  • 0

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