AB7456

Native金黄色葡萄球菌蛋白A (HRP)

Name: 天然Staphylococcus aureus Protein A (HRP) (ab7456)| Abcam中文官网
Brand: Abcam Limited
SKU: AB7456
Price: 1960 CNY
Availability: InStock

Native Staphylococcus aureus Protein A (HRP)

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(20 Publications)

Native Staphylococcus aureus Protein A (HRP) is a Full Length S. aureus Protein A (Spa) protein conjugated to Horseradish Peroxidase (HRP) with >95% purity and suitable for western blot, ELISA, IHC, Dot blot and more.The predicted molecular weight of ab7456 protein is 56 kDa.

- Save time and ensure accurate results - use our S. aureus Protein A (HRP) to probe and detect IgG
- Cited in over 15 publications

查看别名

SAOUHSC_00069, spa, Immunoglobulin G-binding protein A, IgG-binding protein A, Staphylococcal protein A, SpA

关键信息

纯度

>95% SDS-PAGE

表达系统

Native

应用

IM, WB, Dot, IHC-P, ELISA

applications

生物活性

偶联物

HRP

激发波长/发射波长

访问

P02976

不含动物源

不含载体蛋白

种属

Staphylococcus aureus subsp. aureus NCTC 8325

存储溶液

Preservative: 0.01% Gentamicin sulphate Constituents: 1% BSA, 0.88% Sodium chloride, 0.424% Potassium phosphate solution

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "Dot": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"" }, "IM": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"" }, "WB": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"1/10000 - 1/40000", "notes":"" }, "ELISA": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"1/20000 - 1/200000", "notes":"" }, "IHC-P": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"1/1000 - 1/5000", "notes":"" } } }

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产品详情

Molecular Weight (protein A): 42,000 daltons

Extinction Coefficient: 0.1% at 280 nm is 0.14 (E^0.1% of 0.14)

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序列信息

[{"sequence":"","proteinLength":"Full Length","predictedMolecularWeight":"56 kDa","actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Native","expressionSystem":null,"accessionNumber":"P02976","tags":[]}]

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性能和储存信息

运输条件

Blue Ice

储存信息

Avoid freeze / thaw cycle

False

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特殊说明

形式

Liquid

附加说明

Protein A Peroxidase Conjugation was prepared from chromatographically pure Protein A.

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常规信息

功能

Plays a role in the inhibition of the host innate and adaptive immune responses. Possesses five immunoglobulin-binding domains that capture both the fragment crystallizable region (Fc region) and the Fab region (part of Ig that identifies antigen) of immunoglobulins (PubMed : 10805799, PubMed : 2938951, PubMed : 4163007). In turn, Staphylococcus aureus is protected from phagocytic killing via inhibition of Ig Fc region. In addition, the host elicited B-cell response is prevented due to a decrease of antibody-secreting cell proliferation that enter the bone marrow, thereby decreasing long-term antibody production. Inhibits osteogenesis by preventing osteoblast proliferation and expression of alkaline phosphatase, type I collagen, osteopontin and osteocalcin. Acts directly as a pro-inflammatory factor in the lung through its ability to bind and activate tumor necrosis factor alpha receptor 1/TNFRSF1A (By similarity).

序列相似性

Belongs to the immunoglobulin-binding protein SpA family.

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产品实验方案

Visit the General protocols
Visit the Troubleshooting

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靶点信息

See full target information spa

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文献 (20)

Recent publications for all applications. Explore the full list and refine your search

Life (Basel, Switzerland) 15: PubMed40003558

2025

DYRK1A Up-Regulation Specifically Impairs a Presynaptic Form of Long-Term Potentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Aude-Marie Lepagnol-Bestel,Simon Haziza,Julia Viard,Paul A Salin,Arnaud Duchon,Yann Herault,Michel Simonneau

Small (Weinheim an der Bergstrasse, Germany) 19:e2205819 PubMed36564365

2022

Assembly of Immunogenic Protein Particles toward Advanced Synthetic Vaccines.

Applications

Unspecified application

Species

Unspecified reactive species

Shuxiong Chen,Diana H Quan,Gayathri Sam,Victoria Ozberk,Xiaonan T Wang,Peter Halfmann,Manisha Pandey,Michael F Good,Yoshihiro Kawaoka,Warwick J Britton,Bernd H A Rehm

Life science alliance 5: PubMed35914814

2022

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Julia Viard,Yann Loe-Mie,Rachel Daudin,Malik Khelfaoui,Christine Plancon,Anne Boland,Francisco Tejedor,Richard L Huganir,Eunjoon Kim,Makoto Kinoshita,Guofa Liu,Volker Haucke,Thomas Moncion,Eugene Yu,Valérie Hindie,Henri Bléhaut,Clotilde Mircher,Yann Herault,Jean-François Deleuze,Jean-Christophe Rain,Michel Simonneau,Aude-Marie Lepagnol-Bestel

Cell death and differentiation 29:1152-1163 PubMed34839354

2021

ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-κB.

Applications

Unspecified application

Species

Unspecified reactive species

Minho Won,Kyeong Ah Park,Sup Kim,Eunjin Ju,Youngbok Ko,Heonjong Yoo,Hyunju Ro,Jaeseob Lee,Junseo Oh,Eun Gyo Lee,Sang Yean Kim,Suk Woo Nam,Han-Ming Shen,Min-Kyung Yeo,Jin Man Kim,Gang Min Hur

Journal of experimental & clinical cancer research 38:370 PubMed31438997

2019

Topoisomerase inhibitors promote cancer cell motility via ROS-mediated activation of JAK2-STAT1-CXCL1 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jiafei Liu,Like Qu,Lin Meng,Chengchao Shou

Nature communications 10:3218 PubMed31324769

2019

Dopey1-Mon2 complex binds to dual-lipids and recruits kinesin-1 for membrane trafficking.

Applications

Unspecified application

Species

Unspecified reactive species

Divyanshu Mahajan,Hieng Chiong Tie,Bing Chen,Lei Lu

Current biology : CB 29:1002-1018.e7 PubMed30853435

2019

Prdm9 and Meiotic Cohesin Proteins Cooperatively Promote DNA Double-Strand Break Formation in Mammalian Spermatocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Tanmoy Bhattacharyya,Michael Walker,Natalie R Powers,Catherine Brunton,Alexander D Fine,Petko M Petkov,Mary Ann Handel

The Journal of veterinary medical science 81:328-337 PubMed30587673

2018

Serological and histological evaluation of species-specific immunocontraceptive vaccine antigens based on zona pellucida 3 in the small Indian mongoose (Herpestes auropunctatus).

Applications

Unspecified application

Species

Unspecified reactive species

Naotoshi Kuninaga,Makoto Asano,Ryota Matsuyama,Takahiro Minemoto,Takayuki Mori,Masatsugu Suzuki

Nature communications 9:5182 PubMed30518920

2018

NLRP3 lacking the leucine-rich repeat domain can be fully activated via the canonical inflammasome pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Iva Hafner-Bratkovič,Petra Sušjan,Duško Lainšček,Ana Tapia-Abellán,Kosta Cerović,Lucija Kadunc,Diego Angosto-Bazarra,Pablo Pelegrin,Roman Jerala

Nature communications 9:4987 PubMed30478271

2018

Amino acids stimulate the endosome-to-Golgi trafficking through Ragulator and small GTPase Arl5.

Applications

Unspecified application

Species

Unspecified reactive species

Meng Shi,Bing Chen,Divyanshu Mahajan,Boon Kim Boh,Yan Zhou,Bamaprasad Dutta,Hieng Chiong Tie,Siu Kwan Sze,Geng Wu,Lei Lu

View all publications

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Native金黄色葡萄球菌蛋白A (HRP)

Native Staphylococcus aureus Protein A (HRP)

关键信息

纯度

表达系统

标签

应用

生物活性

偶联物

激发波长/发射波长

访问

不含动物源

不含载体蛋白

种属

存储溶液