Native猪Myelin Basic蛋白
Native Pig Myelin Basic Protein
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(1 Publication)
Native Pig Myelin Basic Protein is a Pig Full Length protein, expressed in Native, with >90%, suitable for SDS-PAGE.
查看别名
Myelin basic protein, MBP
- SDS-PAGE
Supplier Data
SDS-PAGE - Native Pig Myelin Basic Protein (AB64311)
ab64311 on SDS-PAGE, MW 21.5kDa.
反应性数据
产品详情
ab64311 (Myelin Basic Protein protein) can be utilized as a substrate for the following active protein kinases:
ab51441 (Active human MNK2 full length protein)
ab55709 (Active human Flt3 / CD135 protein fragment)
ab55716 (Active human Myosin IIIB protein fragment)
ab56636 (Active human MAP4K5 full length protein)
ab60327 (Active mouse Aurora A full length protein)
ab60342 (Active human NEK2 full length protein)
ab60698 (Active human NEK6 full length protein)
ab60860 (Active human IRAK4 full length protein)
ab60867 (Active human HIPK1 protein fragment)
ab60879 (Active human RIP2 protein)
ab60885 (Active human STK3 full length protein)
ab61426 (Active human TAO kinase 2 protein fragment)
ab63169 (Active human TAOK1 protein fragment)
ab63191 (Active human DAP Kinase 1 protein fragment)
ab63192 (Active human ZIP Kinase full length protein)
ab63209 (Active human MEK1 full length protein)
ab64303 (Active human CDK7 + Cyclin H + MNAT1 full length protein)
ab69925 (Active human HIPK4 full length protein)
ab70075 (Active human TSSK2 full length protein)
ab70614 (Active human ROR2 protein fragment)
ab71693 (Active MUSK protein fragment)
ab85275 (Active human PBK full length protein)
ab85276 (Active human NAK full length protein)
ab85293 (Active human SRPK2 full length protein)
ab85295 (Active human SRPK1 full length protein)
ab85297 (Active human MEKK3 full length protein)
ab85299 (Active human MEKK2 full length protein)
ab85601 (Active human HIPK3 protein fragment)
ab85759 (Active human CLK3 full length protein)
ab85838 (Active human PKR protein fragment)
ab89589 (Active human Mps1 full length protein)
ab89591 (Active human STK33 full length protein)
ab89692 (Active human TAK1 + TAB1 protein fragment)
ab89694 (Active human RIPK5 full length protein)
ab89758 (Active human NEK3 full length protein)
ab89852 (Active human ZAK full length protein)
ab101774 (Active human ICK full length protein)
ab101775 (Active human MAP4K4 protein fragment)
ab104027 (Active human MEKK1 protein fragment)
ab105210 (Active human NFkB Inducing Kinase NIK protein fragment)
ab105904 (Active human ERK1 full length protein)
ab107696 (Active human STK39 full length protein)
ab107700 (Active human NLK full length protein)
ab107953 (Active human MAP4K1 protein)
ab119725 (Active human TNIK protein fragment)
ab125544 (Active human NEK11 full length protein)
ab125553 (Active mouse HIPK2 protein fragment)
ab125554 (Active human MAP3K9 protein fragment)
ab125558 (Active human PLK4 protein fragment)
ab125562 (Active human MLK2 protein fragment)
ab125566 (Active human RIP3 full length protein)
ab125574 (Active human YANK2 full length protein)
ab125588 (Active human STK25 full length protein)
ab125614 (Active human NEK9 protein fragment)
ab125622 (Active human ULK2 protein fragment)
ab125630 (Active human MLK3 protein fragment)
ab125631 (Active mouse Tau tubulin kinase 2 protein fragment)
ab125656 (Active human ULK1 protein fragment)
ab126913 (Active human ERK5 full length protein)
ab126926 (Active human BMPR2 protein fragment)
ab133140 (Active human NEK5 protein fragment)
ab133146 (Active human NEK1 protein fragment)
ab139615 (Active human STK36 protein fragment)
ab140807 (Active human ROR1 protein fragment)
ab151882 (Human Smad3 full length protein)
ab155812 (Active ERK2 full length protein)
ab174066 (Active human LIMK1 protein fragment)
序列信息
性能和储存信息
运输条件
推荐的短期储存条件
推荐的长期储存条件
储存信息
补充信息
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
MBP is not just a passive structural element; it binds and interacts with lipids and other proteins to maintain the compact structure of the myelin sheath. MBP forms part of a complex that includes various other proteins and lipids ensuring the stability and function of myelin. Misfolding or altered expression of MBP can compromise myelin integrity affecting the insulation of neural pathways and signal transmission.
Pathways
MBP is an essential component in the pathways of myelination and neural plasticity. It plays a role in the signaling pathways that stimulate the development and maintenance of the myelin sheath. The protein interacts with other elements of the myelin sheath such as proteolipid protein (PLP) and myelin-associated glycoprotein (MAG) to coordinate its formation and repair processes.
特殊说明
形式
Liquid
附加说明
Native pig Myelin Basic Protein was extracted under acidic conditions and further purified by cation chromatography.
常规信息
功能
Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity).
序列相似性
Belongs to the myelin basic protein family.
翻译后修饰
As in other animals, several charge isomers may be produced as a result of optional post-translational modifications, such as phosphorylation of serine or threonine residues, deamidation of glutamine or asparagine residues, citrullination and methylation of arginine residues.. Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1.. Proteolytically cleaved in B cell lysosomes by cathepsin CTSG which degrades the major immunogenic MBP epitope and prevents the activation of MBP-specific autoreactive T cells.
靶点信息
文献 (1)
Recent publications for all applications. Explore the full list and refine your search
Cell reports 37:109892 PubMed34672947
2021
Applications
Unspecified application
Species
Unspecified reactive species
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