Native牛蛋白C (ab62449)
Key features and details
- Expression system: Native
- Purity: > 95% Ion Exchange Chromatography
- Suitable for: SDS-PAGE, Functional Studies
描述
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产品名称
Native牛蛋白C
参阅全部 Protein C 蛋白酶 -
纯度
> 95 % Ion Exchange Chromatography.
Prepared by a modification of the Walker procedure as described by Haley et al. Purity is determined by SDS-PAGE analysis -
表达系统
Native -
蛋白长度
Full length protein -
无动物成分
No -
性质
Native -
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种属
Cow -
额外的序列信息
Source = fresh citrated bovine plasma
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技术指标
Our Abpromise guarantee covers the use of ab62449 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
SDS-PAGE
Functional Studies
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形式
Liquid -
Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituent: 50% Glycerol
常规信息
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别名
- Activation peptide
- Anticoagulant protein C
- APC
see all -
功能
Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845). -
组织特异性
Plasma; synthesized in the liver. -
疾病相关
Thrombophilia due to protein C deficiency, autosomal dominant
Thrombophilia due to protein C deficiency, autosomal recessive -
序列相似性
Belongs to the peptidase S1 family.
Contains 2 EGF-like domains.
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Contains 1 peptidase S1 domain. -
翻译后修饰
The vitamin K-dependent, enzymatic carboxylation of some Glu residues allows the modified protein to bind calcium.
N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide. -
细胞定位
Secreted. Golgi apparatus. Endoplasmic reticulum. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab62449 尚未被引用在任何文献中。