Native牛Factor V蛋白(ab62236)
Key features and details
- Expression system: Native
- Purity: > 95% Affinity purified
- Suitable for: SDS-PAGE, Functional Studies
描述
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产品名称
Native牛Factor V蛋白 -
纯度
> 95 % Affinity purified.
Bovine factor V is purified using conventional chromatographic techniques. Purity is determined by SDS-PAGE analysis. -
表达系统
Native -
蛋白长度
Full length protein -
无动物成分
No -
性质
Native -
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种属
Cow -
额外的序列信息
Source = fresh bovine plasma
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技术指标
Our Abpromise guarantee covers the use of ab62236 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
SDS-PAGE
Functional Studies
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形式
Liquid -
补充说明
Concentartion varies from lot to lot but is between 5-10mg/ml. -
Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Upon delivery aliquot. Store at -80°C. Avoid freeze / thaw cycle.
Constituent: 50% Glycerol
常规信息
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别名
- Activated protein C cofactor
- APC cofactor
- Coagulation factor V
see all -
功能
Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin. -
组织特异性
Plasma. -
疾病相关
Factor V deficiency
Thrombophilia due to activated protein C resistance
Budd-Chiari syndrome
Ischemic stroke
Pregnancy loss, recurrent, 1 -
序列相似性
Belongs to the multicopper oxidase family.
Contains 3 F5/8 type A domains.
Contains 2 F5/8 type C domains.
Contains 6 plastocyanin-like domains. -
结构域
Domain B contains 35 x 9 AA tandem repeats, and 2 x 17 AA repeats. -
翻译后修饰
Thrombin activates factor V proteolytically to the active cofactor, factor Va (formation of a heavy chain at the N-terminus and a light chain at the C-terminus).
Sulfation is required for efficient thrombin cleavage and activation and for full procoagulant activity.
Activated protein C inactivates factor V and factor Va by proteolytic degradation.
Phosphorylation sites are present in the extracellular medium. -
细胞定位
Secreted. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab62236 尚未被引用在任何文献中。