Native牛Factor IX/PTC蛋白(ab62459)
Key features and details
- Expression system: Native
- Purity: > 95% Ion Exchange Chromatography
- Suitable for: SDS-PAGE, Functional Studies
描述
-
产品名称
Native牛Factor IX/PTC蛋白
参阅全部 Factor IX/PTC 蛋白酶 -
纯度
> 95 % Ion Exchange Chromatography.
Purity is assessed by SDS-PAGE analysis. -
表达系统
Native -
蛋白长度
Full length protein -
无动物成分
No -
性质
Native -
-
种属
Cow -
额外的序列信息
prepared from highly purified factor IX by activation with factor XIa, as described by Lindquist et al.
-
技术指标
Our Abpromise guarantee covers the use of ab62459 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
-
应用
SDS-PAGE
Functional Studies
-
形式
Liquid -
补充说明
Concentration varies from lot to lot but is between 5-10mg/ml -
Concentration information loading...
制备和贮存
-
稳定性和存储
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Constituent: 50% Glycerol
常规信息
-
别名
- Christmas Disease
- Christmas factor
- Coagulant factor IX
see all -
功能
Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. -
组织特异性
Synthesized primarily in the liver and secreted in plasma. -
疾病相关
Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB) [MIM:306900]; also known as Christmas disease.
Note=Mutations in position 43 (Oxford-3, San Dimas) and 46 (Cambridge) prevents cleavage of the propeptide, mutation in position 93 (Alabama) probably fails to bind to cell membranes, mutation in position 191 (Chapel-Hill) or in position 226 (Nagoya OR Hilo) prevent cleavage of the activation peptide.
Defects in F9 are the cause of thrombophilia due to factor IX defect (THR-FIX) [MIM:300807]. A hemostatic disorder characterized by a tendency to thrombosis. -
序列相似性
Belongs to the peptidase S1 family.
Contains 2 EGF-like domains.
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Contains 1 peptidase S1 domain. -
结构域
Calcium binds to the gamma-carboxyglutamic acid (Gla) residues and, with stronger affinity, to another site, beyond the Gla domain. -
翻译后修饰
Activated by factor XIa, which excises the activation peptide.
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. -
细胞定位
Secreted. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
-
SDS download
-
Datasheet download
文献 (0)
ab62459 尚未被引用在任何文献中。