小鼠PCSK9多肽(ab32727)
Key features and details
- Purity: > 90% HPLC
描述
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产品名称
小鼠PCSK9多肽
参阅全部 PCSK9 蛋白酶 -
纯度
> 90 % HPLC. -
无动物成分
No -
性质
Synthetic -
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种属
Mouse
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相关产品
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Coimmunogen
技术指标
Our Abpromise guarantee covers the use of ab32727 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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形式
Liquid -
补充说明
- First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
- If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
- Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
- Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
- Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use. -
Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Information available upon request.
常规信息
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别名
- Convertase subtilisin/kexin type 9 preproprotein
- FH3
- HCHOLA3
see all -
功能
May be implicated in the differentiation of cortical neurons and may play a role in cholesterol homeostasis. -
组织特异性
Expressed in neuro-epithelioma, colon carcinoma, hepatic and pancreatic cell lines, and in Schwann cells. -
疾病相关
Defects in PCSK9 are the cause of familial hypercholesterolemia 3 (FH3) [MIM:603776]. FH3 inheritance is autosomal dominant. -
序列相似性
Belongs to the peptidase S8 family.
Contains 1 peptidase S8 domain. -
翻译后修饰
The soluble zymogen undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted enzyme. -
细胞定位
Secreted. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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Datasheet download
文献 (1)
ab32727 被引用在 1 文献中.
- Wang F et al. PCSK9 Modulates Macrophage Polarization-Mediated Ventricular Remodeling after Myocardial Infarction. J Immunol Res 2022:7685796 (2022). PubMed: 35832650