KAT13D / CLOCK多肽(ab5854)
Key features and details
- Purity: > 95% SDS-PAGE
- Suitable for: Blocking
描述
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产品名称
KAT13D / CLOCK多肽
参阅全部 KAT13D / CLOCK 蛋白酶 -
纯度
> 95 % SDS-PAGE. -
无动物成分
No -
性质
Synthetic
相关产品
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Related Products
技术指标
Our Abpromise guarantee covers the use of ab5854 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
Blocking
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形式
Lyophilized -
补充说明
This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and mouse CLOCK, catalog ab3517. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (70-fold) for competitive inhibition of antibody-protein binding reactions.
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Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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复溶Reconstitute with 0.1 mL of distilled water.
常规信息
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别名
- bHLHe8
- Circadian locomoter output cycles kaput protein
- Circadian locomoter output cycles protein kaput
see all -
功能
ARNTL/2-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. Activates transcription of PER1 and PER2. This transcription is inhibited in a feedback loop by PER and CRY proteins. Has intrinsic histone acetyltransferase activity and this enzymatic function contributes to chromatin-remodeling events implicated in circadian control of gene expression (By similarity). Acetylates primarily histones H3 and H4 (By similarity). Acetylates also a non-histone substrate: ARNTL. -
组织特异性
Expressed in all tissues examined including spleen, thymus, prostate, testis, ovary, small intestine, colon, leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in testis and skeletal muscle. Low levels in thymus, lung and liver. Expressed in all brain regions with highest levels in cerebellum. Highly expressed in the suprachiasmatic nucleus (SCN). -
序列相似性
Contains 1 basic helix-loop-helix (bHLH) domain.
Contains 1 PAC (PAS-associated C-terminal) domain.
Contains 2 PAS (PER-ARNT-SIM) domains. -
翻译后修饰
Phosphorylation is dependent on CLOCK-ARNTL heterodimer formation. -
细胞定位
Cytoplasm. Nucleus. Shuffling between the cytoplasm and the nucleus is under circadian regulation and is ARNTL-dependent. Phosphorylated form located in the nucleus. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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Datasheet download
文献 (0)
ab5854 尚未被引用在任何文献中。
