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AB41752

人EAAT2多肽

Human EAAT2 peptide

4

(1 Review)

|

(1 Publication)

Human EAAT2 peptide is a Synthetic blocking peptide. >90% and suitable for BL.

查看别名

EAAT2, GLT1, SLC1A2, Excitatory amino acid transporter 2, Glutamate/aspartate transporter II, Sodium-dependent glutamate/aspartate transporter 2, Solute carrier family 1 member 2

关键信息

纯度

>90%

标签

Tag free

应用

BL

applications

生物活性

No

访问

P43004

不含动物源

No

不含载体蛋白

No

种属

Human

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搭配使用产品

Proteins & Peptides

AB105573

Recombinant Human S100 Calcium Binding Protein A13/S100A13 (His tag N-Terminus)

SDS-PAGE - Recombinant Human S100 Calcium Binding Protein A13/S100A13 (His tag N-Terminus) (AB105573)

  • 0
  • 0
Primary Antibodies

AB205248

Anti-EAAT2 antibody [EPR19798]

20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Frozen sections) - Anti-EAAT2 antibody [EPR19798] (AB205248)

  • 0
  • 0
Primary Antibodies

AB303530

Anti-MiTF antibody [EPR26363-10]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MiTF antibody [EPR26363-10] (AB303530)

  • 4
  • 1
Primary Antibodies

AB172730

Rabbit IgG, monoclonal [EPR25A] - Isotype Control

RabMAb|Advanced Validation|Recombinant

Flow Cytometry - Rabbit IgG, monoclonal [EPR25A] - Isotype Control (AB172730)

  • 0
  • 0
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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "BL": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"1 µg/mL", "notes":"<p></p>" } } }
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产品详情

Reconstitution instructions:

- First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.

- If the peptide doesn't dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.

- Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.

- Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.

- Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

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序列信息

[{"linker":null,"sequence":null,"proteinLength":null,"predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Synthetic","expressionSystem":null,"accessionNumber":"P43004","tags":[]}]
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性能和储存信息

形式
Lyophilized
运输条件
Blue Ice
推荐的短期储存条件
Ambient
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
False
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常规信息

功能

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed : 14506254, PubMed : 15265858, PubMed : 26690923, PubMed : 7521911). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed : 14506254). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed : 14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity).

序列相似性

Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A2 subfamily.

翻译后修饰

Glycosylated.. Palmitoylation at Cys-38 is not required for correct subcellular localization, but is important for glutamate uptake activity.

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产品实验方案

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靶点信息

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed : 14506254, PubMed : 15265858, PubMed : 26690923, PubMed : 7521911). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed : 14506254). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (PubMed : 14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity).
See full target information SLC1A2
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

American journal of physiology. Regulatory, integr 303:R291-300 PubMed22696576

2012

Altered astrocyte glutamate transporter regulation of hypothalamic neurosecretory neurons in heart failure rats.

Applications

Unspecified application

Species

Unspecified reactive species

Evgeniy S Potapenko,Vinicia C Biancardi,Yiqiang Zhou,Javier E Stern
View all publications
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