CREB多肽(ab204856)
Key features and details
- Purity: > 96% HPLC
- Suitable for: HPLC, Functional Studies
描述
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产品名称
CREB多肽
参阅全部 CREB 蛋白酶 -
纯度
> 96 % HPLC. -
无动物成分
No -
性质
Synthetic -
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序列
KRREILSRRPSYR -
氨基酸
109 to 121
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相关产品
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Recombinant Protein
- Recombinant human STK19/G11 protein (ab139624)
- Recombinant human PKC alpha protein (Active) (ab55672)
- Recombinant human cAMP Protein Kinase Catalytic subunit (ab56268)
- Recombinant human PKA beta (catalytic subunit) protein (ab60837)
- Recombinant human PRKACG protein (ab60838)
- Recombinant human PKC beta 2 protein (ab60841)
- Recombinant human PKC delta protein (ab60844)
- Recombinant human PKC zeta protein (ab60848)
- Recombinant human PKC iota protein (ab60850)
- Recombinant human PKC mu/PKD protein (ab60873)
- Recombinant human PKC nu/PRKD3 protein (ab60874)
- Recombinant human PKN2 protein (ab89860)
技术指标
Our Abpromise guarantee covers the use of ab204856 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
HPLC
Functional Studies
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形式
Lyophilized -
补充说明
ab204856 (CREB peptide) can be utilized as a substrate for the following active protein kinases:
ab190396 (Active human KSR1 protein fragment)
ab185259 (Active human KSR2 protein fragment)
ab56268 (Active human cAMP Protein Kinase Catalytic subunit full length protein)
ab60837 (Active human PKA beta (catalytic subunit) full length protein)
ab60838 (Active human PKA gamma (catalytic subunit) full length protein)
ab60839 (Active X. laevis PKC alpha full length protein)
ab55672 (Active human PKC alpha full length protein)
ab60841 (Active human PKC beta 2 full length protein)
ab60844 (Active human PKC delta full length protein)
ab60850 (Active human PKC iota full length protein)
ab89860 (Active human PKN2 full length protein)
ab60873 (Active human PKC mu full length protein)
ab60874 (Active human PKC nu full length protein)
ab60848 (Active human PKC zeta full length protein)
ab60875 (Active human Protein Kinase D2 full length protein)
ab139624 (Active human STK19 full length protein) -
Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Store at -20°C. Avoid freeze / thaw cycle.
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复溶Dilute peptide in 20mM Tris-HCl, pH 7.5 solution to a final concentration of 1 mg/ml. For optimal storage, aliquot diluted product into smaller quantities and store at recommended temperature.
常规信息
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别名
- Active transcription factor CREB
- cAMP response element binding protein
- cAMP response element binding protein 1
see all -
功能
This protein binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. CREB stimulates transcription on binding to the CRE. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Implicated in synchronization of circadian rhythmicity. -
疾病相关
Defects in CREB1 may be a cause of angiomatoid fibrous histiocytoma (AFH) [MIM:612160]. A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. Note=A chromosomal aberration involving CREB1 is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(2;22)(q33;q12) with CREB1 generates a EWSR1/CREB1 fusion gene that is most common genetic abnormality in this tumor type. -
序列相似性
Belongs to the bZIP family.
Contains 1 bZIP domain.
Contains 1 KID (kinase-inducible) domain. -
翻译后修饰
Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR.
Sumoylated by SUMO1. Sumoylation on Lys-304, but not on Lys-285, is required for nuclear localization of this protein. Sumoylation is enhanced under hypoxia, promoting nuclear localization and stabilization. -
细胞定位
Nucleus. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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Datasheet download
文献 (0)
ab204856 尚未被引用在任何文献中。
