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AB204877

Active Poly (Glu，Tyr)多肽

Active Poly (Glu, Tyr) peptide

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(2 Publications)

Active Poly (Glu, Tyr) peptide is a Synthetic peptide. >95% and suitable for FuncS.

查看别名

BRAF1, RAFB1, BRAF, Serine/threonine-protein kinase B-raf, Proto-oncogene B-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1

关键信息

纯度

>95%

标签

Tag free

应用

FuncS

applications

生物活性

Yes

生物学活性

2300 nmol/min/mg Specific activity defined by radiometric assay, nmol of gamma-phosphate from ATP transferred to Unactive MEK1 and ERK1

访问

P15056

不含动物源

No

不含载体蛋白

No

种属

Human

存储溶液

pH: 7.5 Constituents: 0.394% Tris HCl

storage-buffer

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Reactivity", "Dilution Info", "Notes"] }, "values": { "FuncS": { "reactivity":"TESTED_AND_REACTS", "dilution-info":"", "notes":"<p></p>" } } }
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产品详情

Ratio for molar concentration 4:1 Glu, Tyr (amount of each amino acid in the solution).
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序列信息

[{"sequence":"","proteinLength":null,"predictedMolecularWeight":null,"actualMolecularWeight":null,"aminoAcidEnd":0,"aminoAcidStart":0,"nature":"Synthetic","expressionSystem":null,"accessionNumber":"P15056","tags":[]}]
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性能和储存信息

运输条件
Blue Ice
推荐的短期储存条件
-20°C
推荐的长期储存条件
-20°C
储存信息
Avoid freeze / thaw cycle
True
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特殊说明

形式

Liquid

附加说明

Purified by affinity chromatography

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常规信息

功能

Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed : 21441910, PubMed : 29433126). Phosphorylates PFKFB2 (PubMed : 36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed : 1508179).

序列相似性

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.

翻译后修饰

Phosphorylation at Ser-365 by SGK1 inhibits its activity (Ref.8, PubMed:11410590). Phosphorylation at Thr-753 by MAPK1 (PubMed:19710016). Dephosphorylation of Ser-365 by the SHOC2-MRAS-PP1c (SMP) complex consisting of SHOC2, GTP-bound M-Ras/MRAS and the catalytic subunit of protein phosphatase 1 (PPP1CA, PPP1CB or PPP1CC); this relieves inactivation and stimulates kinase activity (PubMed:35768504, PubMed:35830882).. Methylation at Arg-671 decreases stability and kinase activity.. Ubiquitinated by RNF149; which leads to proteasomal degradation. Polyubiquitinated at Lys-578 in response to EGF.

亚细胞定位

Nucleus

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus (Probable). Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway (PubMed : 21441910, PubMed : 29433126). Phosphorylates PFKFB2 (PubMed : 36402789). May play a role in the postsynaptic responses of hippocampal neurons (PubMed : 1508179).
See full target information BRAF
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Communications chemistry 5:5 PubMed36697561

2022

Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors.

Applications

Unspecified application

Species

Unspecified reactive species

Lingzhi Qu,Xiaojuan Chen,Hudie Wei,Ming Guo,Shuyan Dai,Longying Jiang,Jun Li,Sitong Yue,Zhuchu Chen,Yongheng Chen

Molecules (Basel, Switzerland) 23: PubMed30487406

2018

Discovery of a Natural Syk Inhibitor from Chinese Medicine through a Docking-Based Virtual Screening and Biological Assay Study.

Applications

Unspecified application

Species

Unspecified reactive species

Xing Wang,Junfang Guo,Zhongqi Ning,Xia Wu
View all publications
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