Active人TRIM5 gamma多肽(ab41839)
Key features and details
- Active: Yes
- Suitable for: Blocking
描述
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产品名称
Active人TRIM5 gamma多肽 -
生物活性
Blocking the activity of the TRIM5 gamma antibody (ab17203). -
无动物成分
No -
性质
Synthetic -
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种属
Human
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技术指标
Our Abpromise guarantee covers the use of ab41839 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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应用
Blocking
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形式
Liquid -
Concentration information loading...
制备和贮存
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稳定性和存储
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: PBS, 0.1% BSAThis product is an active protein and may elicit a biological response in vivo, handle with caution.
常规信息
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别名
- RING finger protein 88
- RNF88
- TRIM5
see all -
功能
Isoform Alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection. Targets retroviral capsid soon after entry into the cell, and prevents reverse transcription of the virus RNA genome. Isoform Alpha trimers may make multiple contacts with the hexameric lattice of CA proteins which constitute the surface of retrovirion core, and somehow inactivate the virus. Restricts efficiently infection by N-MLV, but not HIV-1. May have E3 ubiquitin-protein ligase activity. -
通路
Protein modification; protein ubiquitination. -
序列相似性
Belongs to the TRIM/RBCC family.
Contains 1 B box-type zinc finger.
Contains 1 B30.2/SPRY domain.
Contains 1 RING-type zinc finger. -
结构域
The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme. -
翻译后修饰
Ubiquitinates itself in a RING finger- and UBE2D2-dependent manner (in vitro). -
细胞定位
Cytoplasm > P-body. Cytoplasmic bodies. - Information by UniProt
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
数据表及文件
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Datasheet download
文献 (0)
ab41839 尚未被引用在任何文献中。
