AB118800

Anti-ZZZ3抗体

Name: ZZZ3抗体 (ab118800)| Abcam中文官网
Brand: Abcam Limited
SKU: AB118800
Price: 4606 CNY
Availability: InStock

Anti-ZZZ3 antibody

Be the first to review this product! Submit a review

(2 Publications)

Rabbit Polyclonal ZZZ3 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ZZZ3 aa 50-100.

查看别名

ZZ-type zinc finger-containing protein 3, ZZZ3

2 Images

Unknown

Immunoprecipitation - Anti-ZZZ3 antibody (AB118800)

Detection of ZZZ3 in Immunoprecipitates of 293T whole cell lysates (1 mg for IP, 20% of IP loaded) using ab118800 at 6 µg/mg lysate for IP and at 1 µg/ml for subsequent Western blot detection.
Detection : Chemiluminescence with an exposure time of 30 seconds.

All lanes:

Immunoprecipitation - Anti-ZZZ3 antibody (ab118800)

Predicted band size: 102 kDa

false

Unknown

Western blot - Anti-ZZZ3 antibody (AB118800)

All lanes:

Western blot - Anti-ZZZ3 antibody (ab118800) at 0.1 µg/mL

Lane 1:

293T whole cell lysate at 50 µg

Lane 2:

293T whole cell lysate at 15 µg

Lane 3:

Jurkat whole cell lysate at 50 µg

Lane 4:

HeLa whole cell lysate at 50 µg

Predicted band size: 102 kDa

true

Exposure time: 3min

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

WB, IP

applications

免疫原

Synthetic Peptide within Human ZZZ3 aa 50-100. The exact immunogen used to generate this antibody is proprietary information.

Q8IYH5

style

left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-10 µg/mg of lysate", "IP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" }, "Chicken": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Chimpanzee": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Dog": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Ferret": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Gorilla": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Horse": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Platypus": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rhesus monkey": { "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

style

left-column

style

left-column

性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

ab118800 was affinity purified using an epitope specific to ZZZ3 immobilized on solid support.

存储溶液

pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: 99% Tris citrate/phosphate

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

style

left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ZZZ3 also known as Zinc Finger ZZ-Type Containing 3 serves as a component of several essential cellular processes. This protein has a molecular mass of approximately 90 kDa. Researchers have identified its expression predominantly in the nucleus across diverse human tissues indicating its widespread functional impact. Mechanically ZZZ3 acts as a transcriptional regulator important for mediating gene expression by interacting with specific DNA sequences.

Biological function summary

ZZZ3 plays a role as part of the ADA2a-containing (ATAC) histone acetyltransferase complex. This complex impacts chromatin remodeling by modifying histone acetylation influencing the accessibility of transcription factors to DNA. The protein's ability to alter chromatin structure makes it significant in regulating gene expression during cell cycle progression and differentiation.

Pathways

ZZZ3 functions prominently within chromatin organization and transcription regulation pathways. It interacts closely with proteins such as GCN5 a histone acetyltransferase to modulate these pathways. Additionally the protein is involved in the transcriptional co-activator role co-operating with various transcription factors to facilitate RNA polymerase II-driven gene transcription.

Altered ZZZ3 function links to conditions like cancer and neurological disorders. It associates with the dysregulation of gene expression observed in these diseases. In cancer ZZZ3 works in conjunction with oncogenes and tumor suppressor genes contributing to tumorigenic processes. Similarly aberrant interaction with proteins involved in neural signaling pathways can implicate ZZZ3 in certain neurological pathologies where it may affect neural development or function.

style

left-column

style

left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

靶点信息

Histone H3 reader that is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation (PubMed : 30217978). Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (PubMed : 19103755).

See full target information ZZZ3

style

left-column

文献 (2)

Recent publications for all applications. Explore the full list and refine your search

The Journal of cell biology 222: PubMed36920342

2023

The exocyst complex is an essential component of the mammalian constitutive secretory pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Conceição Pereira,Danièle Stalder,Georgina S F Anderson,Amber S Shun-Shion,Jack Houghton,Robin Antrobus,Michael A Chapman,Daniel J Fazakerley,David C Gershlick

eLife 10: PubMed33913810

2021

TAZ-CAMTA1 and YAP-TFE3 alter the TAZ/YAP transcriptome by recruiting the ATAC histone acetyltransferase complex.

Applications

Unspecified application

Species

Unspecified reactive species

Nicole Merritt,Keith Garcia,Dushyandi Rajendran,Zhen-Yuan Lin,Xiaomeng Zhang,Katrina A Mitchell,Nicholas Borcherding,Colleen Fullenkamp,Michael S Chimenti,Anne-Claude Gingras,Kieran F Harvey,Munir R Tanas

View all publications

style

left-column

style

left-column

style

right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ZZZ3抗体

Anti-ZZZ3 antibody

Immunoprecipitation - Anti-ZZZ3 antibody (AB118800)

Western blot - Anti-ZZZ3 antibody (AB118800)