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AB223062

Anti-ZRSR2 抗体

Anti-ZRSR2 antibody

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(1 Publication)

Rabbit Polyclonal ZRSR2 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Mouse samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human ZRSR2 aa 150-400.

查看别名

U2AF1-RS2, U2AF1L2, U2AF1RS2, URP, ZRSR2, U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2, Renal carcinoma antigen NY-REN-20, U2(RNU2) small nuclear RNA auxiliary factor 1-like 2, U2AF35-related protein

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZRSR2 antibody (AB223062)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZRSR2 antibody (AB223062)

Paraffin embedded human testis tissue stained for ZRSR2 with ab223062 (1/100) in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-ZRSR2 antibody (AB223062)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-ZRSR2 antibody (AB223062)

HepG2 (human liver hepatocellular carcinoma cell line) cells stained for ZRSR2 (green) using ab223062 (1/100) in ICC/IF. Secondary : Alexa Fluor® 488-conjugated Goat Anti-Rabbit IgG (H+L).

Western blot - Anti-ZRSR2 antibody (AB223062)
  • WB

Supplier Data

Western blot - Anti-ZRSR2 antibody (AB223062)

All lanes:

Western blot - Anti-ZRSR2 antibody (ab223062) at 1/500 dilution

Lane 1:

K562 (human chronic myelogenous leukemia cell line from bone marrow ) whole cell lysate

Lane 2:

HEK-293 (human epithelial cell line from embryonic kidney) whole cell lysate

Lane 3:

mouse heart tissue lysate

Secondary

All lanes:

Goat Anti-Rabbit IgG at 1/50000 dilution

Predicted band size: 58 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Mouse, Human

应用

ICC/IF, IHC-P, WB

applications

免疫原

Recombinant Fragment Protein within Human ZRSR2 aa 150-400. The exact immunogen used to generate this antibody is proprietary information.

Q15696

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein G
纯化说明
Purity >95%
存储溶液
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ZRSR2 (Zinc finger CCCH-type RNA-binding motif and serine/arginine-rich 2) plays a role in splicing influencing the splicing process of pre-mRNA by recognizing the 3' splice site. This protein weighs around 53 kDa and can be found in both the nucleus and cytoplasm of cells. Its expression occurs ubiquitously across various human tissues highlighting its foundational roles in cellular function.
Biological function summary

ZRSR2 is involved in regulating normal splicing via the recognition of U12-type introns. The protein is a part of the spliceosomal complex working closely with other spliceosomal components. This ensures accurate removal of these minor introns during the RNA processing phase. Mutations in ZRSR2 can lead to splicing errors which suggests its importance in gene expression.

Pathways

Splicing and gene expression are significant pathways involving ZRSR2. It is functionally connected to the spliceosomal complex and interacts with snRNP particles like U2AF2 and U2AF1. These interactions highlight ZRSR2's role as a critical player in post-transcriptional modification processes ensuring that genes are correctly expressed.

Malfunctions in ZRSR2 are linked to myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). ZRSR2 mutations can result in an improper splicing of RNA contributing to these hematologic conditions. In the context of these diseases ZRSR2's interaction with related splicing factors such as SF3B1 further emphasizes the impact of defective splicing in the development and progression of these disorders.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing.
See full target information ZRSR2
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

International journal of biological sciences 21:5015-5033 PubMed40860180

2025

Citrus Pectin Supplementation Alleviated Hepatic Lipid Accumulation through Gut Microbiota Indole Lactic Acid Promoting Hepatic Bile Acid Synthesis and Excretion.

Applications

Unspecified application

Species

Unspecified reactive species

Zhijun Pan,Xinyuan Jin,Qing Li,Yuqing Zhou,Yupeng Zeng,Xin Wang,Yufeng Jin,Yu Chen,Dan Li,Wenhua Ling
View all publications
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