JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB67886

Anti-ZNF331抗体

Anti-ZNF331 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Mouse Polyclonal ZNF331 antibody. Carrier free. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ZNF331.

查看别名

RITA, ZNF361, ZNF463, ZNF331, Zinc finger protein 331, C2H2-like zinc finger protein rearranged in thyroid adenomas, Zinc finger protein 361, Zinc finger protein 463

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-ZNF331 antibody (AB67886)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ZNF331 antibody (AB67886)

ab67886 at 10μg/ml staining ZNF331 in Hela cells.

Western blot - Anti-ZNF331 antibody (AB67886)
  • WB

Unknown

Western blot - Anti-ZNF331 antibody (AB67886)

All lanes:

Western blot - Anti-ZNF331 antibody (ab67886) at 1/500 dilution

Lane 1:

ZNF331 transfected 293T cell lysate at 25 µg

Lane 2:

Non-transfected 293T cell lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Predicted band size: 54 kDa

Observed band size: 44 kDa

false

关键信息

宿主种属

Mouse

克隆

Polyclonal

亚型

IgG

不含载体蛋白

Yes

反应种属

Human

应用

WB, ICC/IF

applications

免疫原

Recombinant Full Length Protein corresponding to Human ZNF331.

Q9NQX6

特异性

This antibody is reactive against mammalian transfected lysate.

style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p>NOTE: Product requires purification with Protein A prior to use in ICC/IF.</p>" } } }
style
left-column
style
left-column

性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Protein A
存储溶液
pH: 7.4 Constituents: PBS
运输条件
Blue Ice
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ZNF331 also known as Zinc Finger Protein 331 is a member of the zinc finger protein family and functions as a transcriptional regulator. The protein weighs approximately 63 kDa. It carries zinc finger motifs that enable DNA binding which affects gene expression. ZNF331 frequently occurs in various tissues with higher expression levels in the spleen and lymph nodes. This suggests its role in the immune system or related physiological processes.
Biological function summary

ZNF331 acts as a transcriptional repressor influencing the regulation of target genes by binding to specific DNA sequences. It participates in regulating cell growth and apoptosis processes critical for maintaining cellular homeostasis. ZNF331 interacts with other proteins to form complexes that modulate chromatin structure affecting gene accessibility and transcription. The protein's expression pattern and molecular function indicate its involvement in tissue-specific regulatory mechanisms.

Pathways

Research shows ZNF331 participates in pathways related to cell cycle regulation and apoptotic signaling. It interacts with p53 signaling pathway components an important pathway involved in tumor suppression by triggering cell cycle arrest or apoptosis in response to DNA damage. ZNF331's interaction with such pathways implies its potential role in maintaining cellular integrity. Its related proteins such as p21 and cyclins further emphasize its function in cell cycle modulation.

Research links ZNF331 to various cancers particularly gastric and colorectal cancers. Abnormal expression patterns such as downregulation associate with tumor progression and malignancy. Additionally ZNF331 shows potential involvement in immune-mediated disorders due to its expression in lymphoid tissues. Disruption of its interaction with p53 and related proteins can exacerbate disease symptoms by permitting unchecked cellular proliferation highlighting its importance in oncogenesis and immune function.
style
left-column
style
left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

靶点信息

May be involved in transcriptional regulation. May play a role in spermatogenesis.
See full target information ZNF331
style
left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Oncogene 32:307-17 PubMed22370639

2012

Zinc-finger protein 331, a novel putative tumor suppressor, suppresses growth and invasiveness of gastric cancer.

Applications

IHC-P, WB

Species

Human, Human

J Yu,Q Y Liang,J Wang,Y Cheng,S Wang,T C W Poon,M Y Y Go,Q Tao,Z Chang,J J Y Sung
View all publications
style
left-column
style
left-column
style
right-column

搭配使用产品

Primary Antibodies

AB254938

Anti-VGLL3 antibody

Immunocytochemistry/ Immunofluorescence - Anti-VGLL3 antibody (AB254938)

  • 0
  • 0
Primary Antibodies

AB68071

Anti-TRIM22 antibody

Western blot - Anti-TRIM22 antibody (AB68071)

  • 0
  • 0
Primary Antibodies

AB250993

Anti-USP19 antibody [EPR14816] - BSA and Azide free

RabMAb|Recombinant|KO Validated

Flow Cytometry (Intracellular) - Anti-USP19 antibody [EPR14816] - BSA and Azide free (AB250993)

  • 0
  • 0
Primary Antibodies

AB224221

Anti-WDHD1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-WDHD1 antibody (AB224221)

  • 0
  • 0

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com