Hello. We're improving abcam.com and we'd welcome your feedback.

Hello. We're improving abcam.com and we'd welcome your feedback.

Infomation icon

We haven't added this to the BETA yet

New BETA website

New BETA website

Hello. We're improving abcam.com and we'd welcome your feedback.

Take a look at our BETA site and see what we’ve done so far.

Switch on our new BETA site

Now available

Search and browse selected products

  • A selection of primary antibodies

Purchase these through your usual distributor

In the coming months

  • Additional product types
  • Supporting content
  • Sign in to your account
  • Purchase online

Anti-ZNF238抗体(ab118471)

Submit a review Q&A (1)References (4)
Western blot - Anti-ZNF238 antibody (ab118471)

    Key features and details

    • Rabbit polyclonal to ZNF238
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

    概述

    • 产品名称

      Anti-ZNF238抗体

    • 描述

      兔多克隆抗体to ZNF238

    • 宿主

      Rabbit

    • 经测试应用

      适用于: WBmore details

    • 种属反应性

      与反应: Human
      预测可用于: Mouse, Rat

    • 免疫原

      Recombinant fragment, corresponding to amino acids 228-498 of Human ZNF238 (BC036677).

    • 阳性对照

      • K562 cell lysate.

    • 常规说明

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    性能

    应用

    The Abpromise guarantee

    Abpromise™承诺保证使用ab118471于以下的经测试应用

    “应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。

    应用 Ab评论 说明
    WB
    1/500 - 1/1000. Detects a band of approximately 58 kDa (predicted molecular weight: 58 kDa).
    说明
    WB
    1/500 - 1/1000. Detects a band of approximately 58 kDa (predicted molecular weight: 58 kDa).

    靶标

    • 功能

      Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons (By similarity). Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus.

    • 组织特异性

      Lymphoid tissues, testis, heart, brain, skeletal muscle, and pancreas and, at much lower level, other tissues.

    • 序列相似性

      Contains 1 BTB (POZ) domain.
      Contains 4 C2H2-type zinc fingers.

    • 翻译后修饰

      Phosphorylated upon DNA damage, probably by ATM or ATR.

    • 细胞定位

      Nucleus. Associates with condensed chromatin.
    • Information by UniProt

    • 数据库链接

      see all

    • 别名

      • C2H2171 antibody
      • 58 kDa repressor protein antibody
      • C2H2 171 antibody
      • RP58 antibody
      • TAZ 1 antibody
      • TAZ-1 antibody
      • TAZ1 antibody
      • Transcriptional repressor RP58 antibody
      • Translin associated zinc finger protein 1 antibody
      • Translin-associated zinc finger protein 1 antibody
      • ZBTB18 antibody
      • Zinc finger and BTB domain containing protein 18 antibody
      • Zinc finger and BTB domain-containing protein 18 antibody
      • Zinc finger protein 238 antibody
      • Zinc finger protein C2H2 171 antibody
      • Zinc finger protein C2H2-171 antibody
      • ZN238_HUMAN antibody
      • ZNF238 antibody
      see all

    图片

    • Western blot - Anti-ZNF238 antibody (ab118471)
      Western blot - Anti-ZNF238 antibody (ab118471)
      Anti-ZNF238 antibody (ab118471) at 1/500 dilution + K562 cell lysate

      Predicted band size: 58 kDa

    文献 (4)

    发表研究结果有使用 ab118471？请让我们知道，以便我们可以引用本数据表中的参考文章。

    ab118471 被引用在 4 文献中.

    • Masilamani AP  et al. Calpain-mediated cleavage generates a ZBTB18 N-terminal product that regulates HIF1A signaling and glioblastoma metabolism. iScience 25:104625 (2022). PubMed: 35800763
    • Liang C  et al. Up-regulated miR-155 is associated with poor prognosis in childhood acute lymphoblastic leukemia and promotes cell proliferation targeting ZNF238. Hematology 26:16-25 (2021). PubMed: 33357126
    • Wang J & Che J CircTP63 promotes hepatocellular carcinoma progression by sponging miR-155-5p and upregulating ZBTB18. Cancer Cell Int 21:156 (2021). PubMed: 33685441
    • Fedele V  et al. Epigenetic Regulation of ZBTB18 Promotes Glioblastoma Progression. Mol Cancer Res 15:998-1011 (2017). PubMed: 28512252

    客户评价及客户问答

    Show All 评价 Q&A
    提交评价 提交问题

    Question

    Would like to try this antibody in ChIP.

    Read More
    Answer

    DISCOUNT CODE: ***
    Expiration date: April 5, 2013
    Value: $337

    This code will give you $337 off your next order before the expiration date. To redeem this offer, please submit an Abreview for ab118471 in ChIP and include this code in the “Additional Comments” section so we know the Abreview is for this promotion. Please remember that submission of the Abreview is sufficient for the discount code to become active.
    For more information on how to submit an Abreview, please visit the site: www.abcam.com/Abreviews.

    code will be active once the Abreview has been submitted and can be redeemed in one of the following ways: 1) Call to place your order and mention the code to our customer service department; 2) Include the code in your fax order; 3) Place your order on the web and enter the promotional code.

    Any feedback that you can provide will be greatly appreciated, whether positive or negative. If you have any further questions, please do not hesitate to contact us. We look forward to receiving your Abreview and wish you luck with your research.

    The terms and conditions applicable to this offer can be found here: www.abcam.com/abtrial.

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com