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AB106626

Anti-ZMYM3抗体

Anti-ZMYM3 antibody

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(1 Publication)

Rabbit Polyclonal ZMYM3 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ZMYM3.

查看别名

DXS6673E, KIAA0385, ZNF261, ZMYM3, Zinc finger MYM-type protein 3, Zinc finger protein 261

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-ZMYM3 antibody (AB106626)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ZMYM3 antibody (AB106626)

Immunofluorescence of ZMYM3 in Human brain tissue with ab106626 at 20 ug/mL.

Western blot - Anti-ZMYM3 antibody (AB106626)
  • WB

Unknown

Western blot - Anti-ZMYM3 antibody (AB106626)

All lanes:

Western blot - Anti-ZMYM3 antibody (ab106626) at 1 µg/mL

All lanes:

Human brain tissue lysate at 15 µg

Predicted band size: 152 kDa

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关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

ICC/IF, WB

applications

免疫原

Synthetic Peptide within Human ZMYM3. The exact immunogen used to generate this antibody is proprietary information.

Q14202

特异性

ab106626 will detect all known isoforms. Predicted not to cross-react with other ZMYM protein family members.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
运输条件
Blue Ice
推荐的短期储存时间
Up to 12 months
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ZMYM3 also known as Zinc Finger MYM-Type Containing 3 is a protein with a molecular mass of about 155 kDa. It acts as a transcriptional regulator by binding to specific DNA sequences through its zinc-finger domains. ZMYM3 is mainly expressed in the brain and testes suggesting its role in neural and reproductive functions. The protein localizes primarily in the nucleus where it interacts with chromatin to modulate the expression of target genes.
Biological function summary

There are multiple roles of ZMYM3 in cellular processes. It is part of the CoREST complex a multiprotein scaffold involved in transcriptional repression. Through its participation in this complex ZMYM3 contributes to chromatin remodeling and epigenetic silencing of genes playing a role in maintaining the balance of gene expression necessary for normal cellular operations and development.

Pathways

There are several ways ZMYM3 impacts cellular communication and regulation. The protein is involved in the Notch signaling pathway which is important for cell differentiation proliferation and apoptotic processes. ZMYM3 influences this pathway alongside related proteins such as CoREST and LSD1. Additionally it interacts within the androgen receptor signaling pathway potentially impacting gene transcription relevant to sexual development and hormone response.

There is significant interest in the connection between ZMYM3 and cognitive impairments including X-linked intellectual disability. Mutations or dysregulation in ZMYM3 can lead to disrupted transcriptional control linking the protein to neurological disorders. Another medical condition linked to ZMYM3 is prostate cancer where it may affect androgen receptor pathways thereby implicating interactions with proteins like LSD1 and the androgen receptor itself in the disease's progression.
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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
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靶点信息

Plays a role in the regulation of cell morphology and cytoskeletal organization.
See full target information ZMYM3
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Genes & development 31:260-274 PubMed28242625

2017

ZMYM3 regulates BRCA1 localization at damaged chromatin to promote DNA repair.

Applications

Unspecified application

Species

Unspecified reactive species

Justin W C Leung,Nodar Makharashvili,Poonam Agarwal,Li-Ya Chiu,Renaud Pourpre,Michael B Cammarata,Joe R Cannon,Alana Sherker,Daniel Durocher,Jennifer S Brodbelt,Tanya T Paull,Kyle M Miller
View all publications
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