AB106624

Anti-ZMYM2/RAMP抗体

Name: ZMYM2/RAMP抗体 (ab106624)| Abcam中文官网
Brand: Abcam Limited
SKU: AB106624
Price: 4606 CNY
Availability: InStock

Anti-ZMYM2/RAMP antibody

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(6 Publications)

Rabbit Polyclonal ZMYM2/RAMP antibody. Suitable for WB and reacts with Mouse samples. Cited in 6 publications.

查看别名

FIM, RAMP, ZNF198, ZMYM2, Zinc finger MYM-type protein 2, Fused in myeloproliferative disorders protein, Rearranged in atypical myeloproliferative disorder protein, Zinc finger protein 198

1 Images

Supplier Data

Western blot - Anti-ZMYM2/RAMP antibody (AB106624)

Lane 1:

Western blot - Anti-ZMYM2/RAMP antibody (ab106624) at 0.125 µg/mL

Lane 2:

Western blot - Anti-ZMYM2/RAMP antibody (ab106624) at 0.25 µg/mL

All lanes:

EL4 cell lysate at 15 µg

Predicted band size: 154 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse

应用

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特异性

At least three isoforms of ZMYM2/RAMP are known to exist; ab106624 will detect only the longest isoform. It is predicted to not cross react with other ZMYM protein family members.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.125-0.25 µg/mL", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

运输条件

Blue Ice

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ZMYM2/RAMP also referred to as zinc finger MYM-type protein 2 or Retinoic Acid Modulating Protein mechanically functions as a transcriptional regulator. It has a molecular mass of about 150 kDa and predominantly localizes in the nucleus. The protein is expressed in various tissues with notable presentations in the brain and testis. It forms part of intricate multiprotein complexes which facilitate its function in regulating gene transcription.

Biological function summary

ZMYM2/RAMP influences several cellular functions through its role as a co-regulator of transcription. It notably participates in corepressor complexes like the NuRD complex which modulates chromatin structure and gene expression. This protein's MYM-type zinc fingers bind specifically to DNA or protein partners allowing it to alter expression profiles of genes involved in diverse cellular processes including cell differentiation and development.

Pathways

ZMYM2/RAMP features within several important biological signaling routes including the retinoic acid signaling pathway. This pathway which ZMYM2/RAMP helps regulate is important for development and differentiation. Within this pathway ZMYM2/RAMP interacts with other proteins such as retinoic acid receptors to modulate transcriptional responses. Additionally it connects with the Wnt signaling pathway intersecting at points with well-recognized proteins like β-catenin playing further roles in cell fate determination.

ZMYM2/RAMP exhibits connections to specific cancers and developmental abnormalities. Aberrant expression or mutations in ZMYM2/RAMP have associations with acute promyelocytic leukemia particularly through its fusion with the RARα gene interfering with normal cellular differentiation. Furthermore it shows relevance to certain nervous system disorders through its interaction with proteins involved in neural development marking it as a potential target for understanding and tackling related pathologies.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Involved in the negative regulation of transcription.

See full target information ZMYM2

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文献 (6)

Recent publications for all applications. Explore the full list and refine your search

iScience 28:113059 PubMed40727931

2025

MGA directly recruits SETDB1/ATF7IP for histone H3K9me3 mark on meiosis-related genes in mouse embryonic stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Kousuke Uranishi,Masataka Hirasaki,Masazumi Nishimoto,Robert J Klose,Akihiko Okuda,Ayumu Suzuki

Nucleic acids research 50:3922-3943 PubMed35253893

2022

ZMYM2 restricts 53BP1 at DNA double-strand breaks to favor BRCA1 loading and homologous recombination.

Applications

Unspecified application

Species

Unspecified reactive species

Doohyung Lee,Katja Apelt,Seong-Ok Lee,Hsin-Ru Chan,Martijn S Luijsterburg,Justin W C Leung,Kyle M Miller

Scientific reports 11:9892 PubMed33972635

2021

Endoplasmic reticulum stress regulates the intestinal stem cell state through CtBP2.

Applications

Unspecified application

Species

Unspecified reactive species

Bartolomeus J Meijer,Wouter L Smit,Pim J Koelink,Barbara F Westendorp,Ruben J de Boer,Jonathan H M van der Meer,Jacqueline L M Vermeulen,James C Paton,Adrienne W Paton,Jun Qin,Evelien Dekker,Vanesa Muncan,Gijs R van den Brink,Jarom Heijmans

American journal of human genetics 107:727-742 PubMed32891193

2020

Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations.

Applications

Unspecified application

Species

Unspecified reactive species

Dervla M Connaughton,Rufeng Dai,Danielle J Owen,Jonathan Marquez,Nina Mann,Adda L Graham-Paquin,Makiko Nakayama,Etienne Coyaud,Estelle M N Laurent,Jonathan R St-Germain,Lot Snijders Blok,Arianna Vino,Verena Klämbt,Konstantin Deutsch,Chen-Han Wilfred Wu,Caroline M Kolvenbach,Franziska Kause,Isabel Ottlewski,Ronen Schneider,Thomas M Kitzler,Amar J Majmundar,Florian Buerger,Ana C Onuchic-Whitford,Mao Youying,Amy Kolb,Daanya Salmanullah,Evan Chen,Amelie T van der Ven,Jia Rao,Hadas Ityel,Steve Seltzsam,Johanna M Rieke,Jing Chen,Asaf Vivante,Daw-Yang Hwang,Stefan Kohl,Gabriel C Dworschak,Tobias Hermle,Mariëlle Alders,Tobias Bartolomaeus,Stuart B Bauer,Michelle A Baum,Eva H Brilstra,Thomas D Challman,Jacob Zyskind,Carrie E Costin,Katrina M Dipple,Floor A Duijkers,Marcia Ferguson,David R Fitzpatrick,Roger Fick,Ian A Glass,Peter J Hulick,Antonie D Kline,Ilona Krey,Selvin Kumar,Weining Lu,Elysa J Marco,Ingrid M Wentzensen,Heather C Mefford,Konrad Platzer,Inna S Povolotskaya,Juliann M Savatt,Natalia V Shcherbakova,Prabha Senguttuvan,Audrey E Squire,Deborah R Stein,Isabelle Thiffault,Victoria Y Voinova,Michael J G Somers,Michael A Ferguson,Avram Z Traum,Ghaleb H Daouk,Ankana Daga,Nancy M Rodig,Paulien A Terhal,Ellen van Binsbergen,Loai A Eid,Velibor Tasic,Hila Milo Rasouly,Tze Y Lim,Dina F Ahram,Ali G Gharavi,Heiko M Reutter,Heidi L Rehm,Daniel G MacArthur,Monkol Lek,Kristen M Laricchia,Richard P Lifton,Hong Xu,Shrikant M Mane,Simone Sanna-Cherchi,Andrew D Sharrocks,Brian Raught,Simon E Fisher,Maxime Bouchard,Mustafa K Khokha,Shirlee Shril,Friedhelm Hildebrandt

Scientific reports 10:8390 PubMed32439918

2020

Characterization of the zinc finger proteins ZMYM2 and ZMYM4 as novel B-MYB binding proteins.

Applications

Unspecified application

Species

Unspecified reactive species

Hannah Cibis,Abhiruchi Biyanee,Wolfgang Dörner,Henning D Mootz,Karl-Heinz Klempnauer

Scientific reports 7:5781 PubMed28720858

2017

GSK-3β deletion in dentate gyrus excitatory neuron impairs synaptic plasticity and memory.

Applications

Unspecified application

Species

Unspecified reactive species

Enjie Liu,Ao-Ji Xie,Qiuzhi Zhou,Mengzhu Li,Shujuan Zhang,Shihong Li,Weijin Wang,Xiaochuan Wang,Qun Wang,Jian-Zhi Wang

View all publications

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Anti-ZMYM2/RAMP抗体

Anti-ZMYM2/RAMP antibody

Western blot - Anti-ZMYM2/RAMP antibody (AB106624)

关键信息

宿主种属

克隆

亚型

不含载体蛋白

反应种属

应用

免疫原

特异性