Anti-ZIP-13抗体(ab106586)
Key features and details
- Rabbit polyclonal to ZIP-13
- Suitable for: ICC/IF, WB, IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-ZIP-13抗体 -
描述
兔多克隆抗体to ZIP-13 -
宿主
Rabbit -
特异性
At least two isoforms of ZIP-13 are known to exist; ab106586 will detect both isoforms. ab106586 is predicted to not crossreact with other ZIP family members. -
经测试应用
适用于: ICC/IF, WB, IHC-Pmore details -
种属反应性
与反应: Human -
免疫原
Synthetic peptide corresponding to Human ZIP-13 (N terminal).
Database link: NP_001121697 -
阳性对照
- K562 cell lysate
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at 4°C (stable for up to 12 months). -
存储溶液
pH: 7.2
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading... -
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab106586于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| ICC/IF |
Use a concentration of 20 µg/ml.
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| WB |
Use a concentration of 1 µg/ml. Predicted molecular weight: 39 kDa.
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| IHC-P |
Use at an assay dependent concentration.
|
| 说明 |
|---|
|
ICC/IF
Use a concentration of 20 µg/ml. |
|
WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 39 kDa. |
|
IHC-P
Use at an assay dependent concentration. |
靶标
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功能
Acts as a zinc-influx transporter. -
疾病相关
Defects in SLC39A13 are the cause of Ehlers-Danlos syndrome-like spondylocheirodysplasia (SCD-EDS) [MIM:612350]. SCD-EDS is a 'spondylocheiro dysplastic form of Ehlers-Danlos syndrome'. The syndrome consists of a generalized skeletal dysplasia involving mainly the spine (spondylo) and striking clinical abnormalities of the hands (cheiro) in addition to the EDS-like features. Clinical features included postnatal growth retardation, moderate short stature, protuberant eyes with bluish sclerae, hands with finely wrinkled palms, atrophy of the thenar muscles, and tapering fingers. Patients have thin, hyperelastic skin and hypermobile small joints consistent with an Ehlers-Danlos-like phenotype. Radiologic features included mild to moderate platyspondyly, mild to moderate osteopenia of the spine, small ileum, flat proximal femoral epiphyses, short, wide femoral necks, and broad metaphyses (elbows, knees, wrists, and interphalangeal joints). -
序列相似性
Belongs to the ZIP transporter (TC 2.A.5) family. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 91252 Human
- Omim: 608735 Human
- SwissProt: Q96H72 Human
- Unigene: 523664 Human
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形式
There are 2 isoforms produced by alternative splicing. -
别名
- FLJ25785 antibody
- LIV-1 subfamily of ZIP zinc transporter 9 antibody
- LZT-Hs9 antibody
see all
图片
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Western blot - Anti-ZIP-13 antibody (ab106586)Anti-ZIP-13 antibody (ab106586) at 1 µg/ml + K562 cell lysate at 15 µg
Predicted band size: 39 kDa -
Immunocytochemistry/ Immunofluorescence - Anti-ZIP-13 antibody (ab106586)Immunofluorescence of ZIP-13 in Human spleen tissue with ab106586 at 20 ug/mL.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZIP-13 antibody (ab106586)Immunohistochemistry of ZIP-13 in Human spleen tissue with ab106586 at 2.5 μg/mL.
实验方案
数据表及文件
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SDS download
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Datasheet download
文献 (2)
ab106586 被引用在 2 文献中.
- Chen Z et al. Zinc ameliorates human aortic valve calcification through GPR39 mediated ERK1/2 signalling pathway. Cardiovasc Res 117:820-835 (2021). PubMed: 32259211
- Cheng X et al. Zinc transporter SLC39A13/ZIP13 facilitates the metastasis of human ovarian cancer cells via activating Src/FAK signaling pathway. J Exp Clin Cancer Res 40:199 (2021). PubMed: 34154618