AB200376

Anti-Zinc finger MIZ domain-containing蛋白1抗体- N-terminal

Name: Zinc finger MIZ domain-containing protein 1抗体- N-terminal (ab200376)| Abcam中文官网
Brand: Abcam Limited
SKU: AB200376

Anti-Zinc finger MIZ domain-containing protein 1 antibody - N-terminal

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(1 Publication)

Rabbit Polyclonal Zinc finger MIZ domain-containing protein 1 antibody. N-terminal. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ZMIZ1.

查看别名

KIAA1224, RAI17, ZIMP10, ZMIZ1, Zinc finger MIZ domain-containing protein 1, PIAS-like protein Zimp10, Retinoic acid-induced protein 17

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Zinc finger MIZ domain-containing protein 1 antibody - N-terminal (AB200376)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Zinc finger MIZ domain-containing protein 1 antibody - N-terminal (AB200376)

Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue labeling Zinc finger MIZ domain-containing protein 1 with ab200376 at 1/40 dilution.

Supplier Data

Western blot - Anti-Zinc finger MIZ domain-containing protein 1 antibody - N-terminal (AB200376)

6% SDS-PAGE

All lanes:

Western blot - Anti-Zinc finger MIZ domain-containing protein 1 antibody - N-terminal (ab200376) at 1/200 dilution

All lanes:

Skov3 cell lysate at 40 µg

Predicted band size: 115 kDa

false

Exposure time: 2min

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

WB, IHC-P

applications

免疫原

Synthetic Peptide within Human ZMIZ1. The exact immunogen used to generate this antibody is proprietary information.

Q9ULJ6

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/25 - 1/100", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Zinc finger MIZ domain-containing protein 1 also known as ZMIZ1 acts mechanically as a transcriptional co-activator. It has a molecular weight of approximately 135 kDa. ZMIZ1 contains a zinc finger domain which is a typical feature for proteins that interact with DNA. This protein is expressed in a variety of tissues including the brain and immune system suggesting diverse roles in cellular processes. The zinc finger MIZ domain facilitates interaction with other proteins and allows it attachment to DNA enabling regulation of transcriptional activity.

Biological function summary

ZMIZ1 influences gene expression by binding with other transcription factors including androgen receptor and Smad proteins to regulate DNA transcription. It is part of protein complexes that modulate various signaling pathways impacting cellular growth and differentiation. The involvement in such complexes reveals its role in fine-tuning transcription processes required for normal cellular functions. The co-activation function of ZMIZ1 can influence the expression of genes that are important for both embryonic and hematopoietic development.

Pathways

ZMIZ1 integrates within the TGF-beta signaling and androgen receptor pathways. In the TGF-beta pathway ZMIZ1 works alongside Smad proteins to enhance the transcriptional responses helping control cell proliferation and apoptosis. In the androgen receptor pathway it aids androgen receptor to activate target gene transcription. These interactions position ZMIZ1 as a central player in regulating processes controlled by those pathways potentially influencing cellular development and oncogenesis.

ZMIZ1 associates with cancer and autoimmune diseases. Research shows its overexpression in certain cancers such as prostate cancer where it might amplify androgen receptor signaling contributing to cancer progression. The protein's connection to autoimmune disorders involves interactions with other immune-related proteins which when dysregulated can lead to improper immune responses. Understanding ZMIZ1 signaling better might offer insights into therapeutic strategies for these conditions.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Acts as a transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes AR sumoylation. The stimulation of AR activity is dependent upon sumoylation (PubMed : 14609956, PubMed : 26522984). Also functions as a transcriptional coactivator in the TGF-beta signaling pathway by increasing the activity of the SMAD3/SMAD4 transcriptional complex (PubMed : 16777850). Involved in transcriptional activation of a subset of NOTCH1 target genes including MYC. Involved in thymocyte and T cell development (By similarity). Involved in the regulation of postmitotic positioning of pyramidal neurons in the developing cerebral cortex (PubMed : 30639322).

See full target information ZMIZ1

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Nephrology (Carlton, Vic.) 29:825-837 PubMed39401868

2024

POU2F2 activates the Akt/mTOR signalling pathway and enhances B lymphocyte function during diabetic kidney disease by promoting PIK3CD transcription.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoxia Li,Shukun Cao,Xiaolin Zi,Haiqiao Yu,Chunmei Mao

View all publications

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Anti-Zinc finger MIZ domain-containing蛋白1抗体- N-terminal

Anti-Zinc finger MIZ domain-containing protein 1 antibody - N-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Zinc finger MIZ domain-containing protein 1 antibody - N-terminal (AB200376)

Western blot - Anti-Zinc finger MIZ domain-containing protein 1 antibody - N-terminal (AB200376)