Anti-ZIC3抗体(ab133153)
Key features and details
- Goat polyclonal to ZIC3
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-ZIC3抗体
参阅全部 ZIC3 一抗 -
描述
山羊多克隆抗体to ZIC3 -
宿主
Goat -
特异性
ab133153 is NOT expected to cross-react with other ZIC proteins. -
经测试应用
适用于: IHC-Pmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Rabbit, Cow, Dog, Pig
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免疫原
Synthetic peptide:
C-HVDNNQVHLGLR
with a Cysteine residue linker, corresponding to internal sequence amino acids 178-189 of Human ZIC3 NP_003404.1. -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA -
Concentration information loading... -
纯度
Immunogen affinity purified -
纯化说明
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab133153于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度；实际最佳的稀释度/浓度应由使用者检定。
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P |
Use a concentration of 5 - 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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| 说明 |
|---|
|
IHC-P
Use a concentration of 5 - 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
靶标
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功能
Acts as transcriptional activator. Required in the earliest stages in both axial midline development and left-right (LR) asymmetry specification. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'. -
疾病相关
Heterotaxy, visceral, 1, X-linked
VACTERL association X-linked with or without hydrocephalus
Congenital heart defects, multiple types, 1, X-linked -
序列相似性
Belongs to the GLI C2H2-type zinc-finger protein family.
Contains 5 C2H2-type zinc fingers. -
结构域
The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation. -
细胞定位
Nucleus. Cytoplasm. Localizes in the cytoplasm in presence of MDFIC overexpression (By similarity). Translocation to the nucleus requires KPNA1 or KPNA6. - Information by UniProt
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数据库链接
- Entrez Gene: 7547 Human
- Entrez Gene: 22773 Mouse
- Entrez Gene: 367944 Rat
- Omim: 300265 Human
- SwissProt: O60481 Human
- SwissProt: Q62521 Mouse
- Unigene: 111227 Human
- Unigene: 255890 Mouse
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别名
- Heterotaxy 1 antibody
- HTX antibody
- HTX1 antibody
see all
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab133153 尚未被引用在任何文献中。