AB19356

Anti-ZHX1抗体

Name: ZHX1抗体 (ab19356)| Abcam中文官网
Brand: Abcam Limited
SKU: AB19356
Price: 4606 CNY
Availability: InStock

Anti-ZHX1 antibody

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(5 Publications)

Rabbit Polyclonal ZHX1 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Cited in 5 publications.

查看别名

Zinc fingers and homeoboxes protein 1, ZHX1

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZHX1 antibody (AB19356)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZHX1 antibody (AB19356)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lung carcinoma tissue labelling ZHX1 with ab19356 at 1/1000 (1μg/ml). Detection : DAB.

Unknown

Western blot - Anti-ZHX1 antibody (AB19356)

All lanes:

Western blot - Anti-ZHX1 antibody (ab19356) at 0.1 µg/mL

Lane 1:

HeLa whole cell lysate at 15 µg

Lane 2:

HEK293T whole cell lysate at 15 µg

Lane 3:

Jurkat whole cell lysate at 15 µg

Lane 4:

TCML-1 whole cell lysate at 15 µg

Lane 5:

NIH-3T3 whole cell lysate at 15 µg

Predicted band size: 98 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Mouse, Human

应用

WB, IHC-P

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/2000", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "" }, "Mouse": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "" }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7 - 8 Preservative: 0.09% Sodium azide Constituents: PBS, 1.815% Tris, 1.764% Sodium citrate

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

Zinc Fingers and Homeoboxes 1 (ZHX1) known also as ZNF908 is a zinc finger-containing protein with a molecular mass of roughly 97 kDa. Consisting of three C2H2-type zinc fingers and five homeodomains it functions primarily as a transcriptional repressor. ZHX1 is expressed in a wide range of tissues including the liver kidney and spleen. Through its ability to dimerize ZHX1 interacts with DNA regulating gene transcription by binding to specific promoters.

Biological function summary

The protein plays a role in modulating gene expression by forming homodimers or heterodimers with other transcription factors such as ZHX2 and ZHX3. ZHX1 represses the transcription of target genes that are critical for cell growth and differentiation. In this process ZHX1 can join in a multi-protein complex further influencing transcriptional activity. This multifaceted role signifies its involvement in maintaining normal cellular function and growth.

Pathways

ZHX1 exerts influence within the calcium signaling pathway and cell cycle regulation. It participates in pathways that control cellular proliferation by interacting with proteins such as cyclins and cyclin-dependent kinases. In calcium signaling ZHX1 modulates gene expression in response to calcium ion fluctuations affecting cellular processes like apoptosis and metabolism. These interactions demonstrate ZHX1's important role in regulating complex cellular responses.

Studies link ZHX1 to liver cancer and nephritic syndrome. Its interaction with proteins like Cyclin D1 contributes to the abnormal cell proliferation observed in hepatocellular carcinoma. In nephritic syndrome altered expression of ZHX1 affects albumin synthesis influencing disease progression. Understanding these connections highlights ZHX1 as a potential biomarker and therapeutic target in these conditions.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Acts as a transcriptional repressor. Increases DNMT3B-mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins.

See full target information ZHX1

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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:10496 PubMed39627214

2024

ATAD5-BAZ1B interaction modulates PCNA ubiquitination during DNA repair.

Applications

Unspecified application

Species

Unspecified reactive species

Yeongjae Kim,Na Young Ha,Mi-Sun Kang,Eunjin Ryu,Geunil Yi,Juyeong Yoo,Nalae Kang,Byung-Gyu Kim,Kyungjae Myung,Sukhyun Kang

Hepatology research : the official journal of the Japan Society of Hepatology : PubMed39207766

2024

Elevated nuclear expression of ZHX1 correlates with poor prognosis in hepatocellular carcinoma (HCC): Comparison of nuclear and cytoplasmic distribution of the ZHX family in HCC cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yu-Hong Ma,Shinya Maekawa,Shinichi Takano,Tatsuya Yamaguchi,Takeshi Ishida,Shinya Takaoka,Masaru Muraoka,Yasuyuki Komiyama,Hitomi Takada,Yuichiro Suzuki,Mitsuaki Sato,Jianglin Fan,Nobuyuki Enomoto

The American journal of clinical nutrition 117:1195-1210 PubMed36963568

2023

Uncovering the gastrointestinal passage, intestinal epithelial cellular uptake, and AGO2 loading of milk miRNAs in neonates using xenomiRs as tracers.

Applications

Unspecified application

Species

Unspecified reactive species

Patrick Philipp Weil,Susanna Reincke,Christian Alexander Hirsch,Federica Giachero,Malik Aydin,Jonas Scholz,Franziska Jönsson,Claudia Hagedorn,Duc Ninh Nguyen,Thomas Thymann,Anton Pembaur,Valerie Orth,Victoria Wünsche,Ping-Ping Jiang,Stefan Wirth,Andreas C W Jenke,Per Torp Sangild,Florian Kreppel,Jan Postberg

Nature methods 19:959-968 PubMed35927480

2022

PROBER identifies proteins associated with programmable sequence-specific DNA in living cells.

Applications

Unspecified application

Species

Unspecified reactive species

Smarajit Mondal,Muthukumar Ramanathan,Weili Miao,Robin M Meyers,Deepti Rao,Vanessa Lopez-Pajares,Zurab Siprashvili,David L Reynolds,Douglas F Porter,Ian Ferguson,Poornima Neela,Yang Zhao,Lindsey M Meservey,Margaret Guo,Yen-Yu Yang,Lin Li,Yinsheng Wang,Paul A Khavari

Journal of cellular biochemistry 114:2323-33 PubMed23686912

2013

The SUMOylation of zinc-fingers and homeoboxes 1 (ZHX1) by Ubc9 regulates its stability and transcriptional repression activity.

Applications

Unspecified application

Species

Unspecified reactive species

Shuliang Chen,Xiao Yu,Quan Lei,Lixin Ma,Deyin Guo

View all publications

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Anti-ZHX1抗体

Anti-ZHX1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZHX1 antibody (AB19356)

Western blot - Anti-ZHX1 antibody (AB19356)