AB254654

Anti-ZFHX4抗体

Name: ZFHX4抗体 (ab254654)| Abcam中文官网
Brand: Abcam Limited
SKU: AB254654
Price: 5791 CNY
Availability: InStock

Anti-ZFHX4 antibody

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(2 Publications)

Rabbit Polyclonal ZFHX4 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Zinc finger homeobox protein 4 aa 400-600.

查看别名

Zinc finger homeobox protein 4, Zinc finger homeodomain protein 4, ZFH-4, ZFHX4

1 Images

Immunocytochemistry/ Immunofluorescence - Anti-ZFHX4 antibody (AB254654)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ZFHX4 antibody (AB254654)

PFA fixed, Triton X-100 permeabilized A549 (Human lung carcinoma cell line) cells labeling ZFHX4 using ab254654 at 4µg/ml (green) in ICC/IF.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human Zinc finger homeobox protein 4 aa 400-600. The exact immunogen used to generate this antibody is proprietary information.

Q86UP3

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100</p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ZFHX4 also known as zinc finger homeobox 4 is a transcription factor involved in regulating gene expression. It has a molecular mass of approximately 384 kDa. This protein is large and contains multiple zinc finger domains allowing it to bind DNA and influence transcription of specific genes. ZFHX4 is widely expressed in human tissues with higher expression noted in the brain and eyes suggesting its important role in neural function and ocular development.

Biological function summary

ZFHX4 plays a role in neural development and maintenance. This transcription factor is not known to be part of a larger protein complex but it interacts with several other proteins to control neuronal differentiation and maturation. In the retina ZFHX4 influences the growth and specialization of neural cells. This role in cellular development highlights its importance in maintaining the normal function of neural tissues.

Pathways

ZFHX4 influences both the Wnt signaling and Notch signaling pathways which are critical in development and cellular differentiation. Within these pathways it interacts with proteins such as β-catenin in the Wnt pathway and Notch receptors in the Notch pathway. These interactions ensure proper functioning of the pathways facilitating cell proliferation and differentiation during development.

ZFHX4 associates with ocular diseases such as Axenfeld-Rieger syndrome and corneal dystrophy. Mutations or dysregulation of ZFHX4 can lead to developmental defects in the eye. In Axenfeld-Rieger syndrome ZFHX4 interacts with other transcription factors like FOXC1 affecting the development of the anterior segment of the eye. In corneal dystrophy the interruption in its regulation can lead to abnormal corneal cell function and vision impairment.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation.

See full target information Zinc finger homeobox protein 4

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Developmental dynamics : an official publication of the American Association of Anatomists 254:257-271 PubMed39320016

2024

Expression analysis of genes including Zfhx4 in mice and zebrafish reveals a temporospatial conserved molecular basis underlying craniofacial development.

Applications

Unspecified application

Species

Unspecified reactive species

Shujie Liu,Lin Xu,Makoto Kashima,Rika Narumi,Yoshifumi Takahata,Eriko Nakamura,Hirotoshi Shibuya,Masaru Tamura,Yuki Shida,Toshihiro Inubushi,Yuko Nukada,Masaaki Miyazawa,Kenji Hata,Riko Nishimura,Takashi Yamashiro,Junichi Tasaki,Hiroshi Kurosaka

Nature communications 14:6446 PubMed37833281

2023

Rewiring of the promoter-enhancer interactome and regulatory landscape in glioblastoma orchestrates gene expression underlying neurogliomal synaptic communication.

Applications

Unspecified application

Species

Unspecified reactive species

Chaitali Chakraborty,Itzel Nissen,Craig A Vincent,Anna-Carin Hägglund,Andreas Hörnblad,Silvia Remeseiro

View all publications

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Anti-ZFHX4抗体

Anti-ZFHX4 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ZFHX4 antibody (AB254654)