JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB272580

Anti-ZFAND5抗体

Anti-ZFAND5 antibody

Be the first to review this product! Submit a review

|

(0 Publication)

Rabbit Polyclonal ZFAND5 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human ZFAND5 aa 50-200.

查看别名

ZA20D2, ZNF216, ZFAND5, AN1-type zinc finger protein 5, Zinc finger A20 domain-containing protein 2, Zinc finger protein 216

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZFAND5 antibody (AB272580)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZFAND5 antibody (AB272580)

Paraffin-embedded formalin-fixed Human placenta tissue stained for ZFAND5 using ab272580 at 1/500 in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-ZFAND5 antibody (AB272580)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ZFAND5 antibody (AB272580)

PFA fixed, Triton X-100 permeablized human cell line A431 labeling ZFAND5 (green) using ab272580 at 2 ug/ml in ICC/IF analysis.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

No

反应种属

Human

应用

ICC/IF, IHC-P, WB

applications

免疫原

Recombinant Fragment Protein within Human ZFAND5 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.

O76080

style
left-column

搭配使用产品

Primary Antibodies

AB262871

Anti-p19 INK4d antibody

Immunocytochemistry/ Immunofluorescence - Anti-p19 INK4d antibody (AB262871)

  • 0
  • 0
Primary Antibodies

AB314456

Anti-FAP antibody [RM1080]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAP antibody [RM1080] (AB314456)

  • 0
  • 0
Primary Antibodies

AB185225

Anti-RRP7A antibody [EPR14412] - C-terminal

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-RRP7A antibody [EPR14412] - C-terminal (AB185225)

  • 0
  • 0
Primary Antibodies

AB139688

Anti-CSN4 antibody [EPR7453]

RabMAb|Recombinant

Western blot - Anti-CSN4 antibody [EPR7453] (AB139688)

  • 0
  • 0
style
left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
style
left-column
style
left-column

性能和储存信息

形式
Liquid
纯化工艺
Affinity purification Immunogen
存储溶液
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
运输条件
Blue Ice
推荐的短期储存时间
1-2 weeks
推荐的短期储存条件
+4°C
推荐的长期储存条件
-20°C
分装信息
Upon delivery aliquot
储存信息
Avoid freeze / thaw cycle
style
left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ZFAND5 also known as ZNF216 is a protein involved mechanically in protein degradation processes. It has a molecular mass of approximately 24 kDa. This protein is known for its expression in various tissues including muscle and liver. ZFAND5 functions as an adaptor that facilitates the recruitment of proteins to proteasomes aiding in the removal of misfolded or damaged proteins within cells.
Biological function summary

ZFAND5 has a significant role in maintaining cellular protein homeostasis. The protein is part of a complex involving the ubiquitin-proteasome system. This complex acts to recognize proteins marked for degradation. By interacting with the proteasome ZFAND5 enhances the degradation process which is essential for cellular health and function. Its activity ensures the smooth turnover of cellular proteins preventing accumulation that can lead to cellular stress.

Pathways

ZFAND5 participates in protein degradation pathways including the ubiquitin-proteasome pathway and the autophagy-lysosome pathway. In the ubiquitin-proteasome pathway ZFAND5 works alongside ubiquitin tagging proteins for destruction. The interplay with other key proteins like ubiquitin ligase highlights its importance in ensuring proteins are correctly degraded and recycled maintaining cellular balance and function.

Aberrant function or expression of ZFAND5 relates to neurodegenerative diseases such as Alzheimer's disease. In Alzheimer's the failing protein degradation can lead to harmful accumulation of proteins like amyloid-beta in which ZFAND5's role becomes critical. Additionally the protein associates with chronic inflammatory disorders where proper protein turnover is disrupted connecting with inflammatory mediators through faulty pathways. Understanding ZFAND5's activity offers insights into tackling these conditions effectively.
style
left-column
style
left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

靶点信息

Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Also inhibits tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation.
See full target information ZFAND5
style
left-column
style
left-column
style
right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。
详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com