AB99930

Anti-ZC3H11A 抗体

Name: ZC3H11A抗体 (ab99930)| Abcam中文官网
Brand: Abcam Limited
SKU: AB99930
Price: 4388 CNY
Availability: InStock

Anti-ZC3H11A antibody

Be the first to review this product! Submit a review

(4 Publications)

Rabbit Polyclonal ZC3H11A antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ZC3H11A aa 300-600.

查看别名

KIAA0663, ZC3HDC11A, ZC3H11A, Zinc finger CCCH domain-containing protein 11A

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZC3H11A antibody (AB99930)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZC3H11A antibody (AB99930)

ab99930, at 1/100 dilution, staining ZC3H11A in formalin-fixed paraffin-embedded Human breast carcinoma tissue.

Unknown

Western blot - Anti-ZC3H11A antibody (AB99930)

All lanes:

Western blot - Anti-ZC3H11A antibody (ab99930) at 1/500 dilution

Lane 1:

Human fetal brain lysate

Lane 2:

Human fetal lung lysate

Lane 3:

Human fetal kidney lysate

Predicted band size: 89 kDa

false

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

IHC-P, WB

applications

免疫原

Recombinant Fragment Protein within Human ZC3H11A aa 300-600. The exact immunogen used to generate this antibody is proprietary information.

O75152

style

left-column

反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

style

left-column

style

left-column

性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Protein A

存储溶液

Preservative: 0.02% Sodium azide

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

style

left-column

补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ZC3H11A also known as zinc finger CCCH-type containing 11A is a protein encoded by the ZC3H11A gene. With a molecular mass of approximately 97 kDa this protein can be found expressed in various tissues with elevated levels in the brain heart and liver. Mechanically ZC3H11A functions as an RNA-binding protein participating in interactions with mRNA molecules. It contains a zinc finger domain that facilitates its interactions with nucleic acids influencing RNA stability and processing.

Biological function summary

This protein has a role in regulating mRNA stability and nuclear export. It often acts as a part of the larger mRNA export complex which includes other proteins that facilitate the transport of mRNA from the nucleus to the cytoplasm. By participating in the control of gene expression at the post-transcriptional level ZC3H11A contributes to cellular homeostasis and response to stress stimuli.

Pathways

This protein functions in the mRNA processing and transport pathways. It interacts with TREX (Transcription/Export) complex components such as Aly/REF export factor (ALYREF) to ensure proper mRNA export from the nucleus. ZC3H11A also integrates into the post-transcriptional gene regulation pathway aligning with proteins like THOC1 and THOC5 ensuring the precise control of gene expression by managing RNA fate within the cell.

Mutations or dysregulation of the ZC3H11A protein have implications in neurodegenerative diseases particularly those affecting mRNA processing and transport. For instance aberrant function of this protein has been studied in the context of Alzheimer's disease where RNA transport misregulation plays a role. ZC3H11A's connection to the THOC complex which is important in RNA metabolism links it to oncology where altered mRNA export mechanisms can contribute to cancer progression.

style

left-column

style

left-column

产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

靶点信息

Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed : 22928037, PubMed : 37356722). Binds RNA (PubMed : 29610341, PubMed : 37356722).. (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed : 29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed : 37356722).

See full target information ZC3H11A

style

left-column

文献 (4)

Recent publications for all applications. Explore the full list and refine your search

eLife 12: PubMed40864167

2025

mutations cause high myopia by triggering PI3K-AKT and NF-κB-mediated signaling pathway in humans and mice.

Applications

Unspecified application

Species

Unspecified reactive species

Chong Chen,Qian Liu,Cheng Tang,Yu Rong,Xinyi Zhao,Dandan Li,Fan Lu,Jia Qu,Xinting Liu

Nature communications 16:231 PubMed39747894

2025

L3MBTL3 and STAT3 collaboratively upregulate SNAIL expression to promote metastasis in female breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jianpeng Xiao,Jie Wang,Jialun Li,Jie Xiao,CuiCui Liu,Libi Tan,Yanhong Tu,Ruifang Yang,Yujie Pei,Minghua Wang,Jiemin Wong,Binhua P Zhou,Jing Li,Jing Feng

Frontiers in microbiology 14:1296725 PubMed38033582

2023

Analysis of the mRNA export protein ZC3H11A in HCMV infection and pan-cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jiawen Li,Min Song,Zhen Liu,Fulong Nan,Bin Wang,Dongmeng Qian,Ming Hu

The Journal of biological chemistry 299:104959 PubMed37356722

2023

The RNA-binding protein ZC3H11A interacts with the nuclear poly(A)-binding protein PABPN1 and alters polyadenylation of viral transcripts.

Applications

Unspecified application

Species

Unspecified reactive species

Katharina Kases,Erik Schubert,Zamaneh Hajikhezri,Mårten Larsson,Priya Devi,Mahmoud Darweesh,Leif Andersson,Göran Akusjärvi,Tanel Punga,Shady Younis

View all publications

style

left-column

style

left-column

style

right-column

Abcam Product Promise

我们致力于为您的研究提供高质量的试剂，为您科研的每一步提供支持。若我们的产品未能达到预期性能，我们向您提供 Abcam Product Promise 保障。

详情请参阅我们的条款与条件。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ZC3H11A 抗体

Anti-ZC3H11A antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZC3H11A antibody (AB99930)

Western blot - Anti-ZC3H11A antibody (AB99930)