AB241612

Anti-ZC3H11A抗体

Name: ZC3H11A抗体 (ab241612)| Abcam中文官网
Brand: Abcam Limited
SKU: AB241612
Price: 4864 CNY
Availability: InStock

Anti-ZC3H11A antibody

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(2 Publications)

Rabbit Polyclonal ZC3H11A antibody. Suitable for IHC-P, IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ZC3H11A aa 700-750.

查看别名

KIAA0663, ZC3HDC11A, ZC3H11A, Zinc finger CCCH domain-containing protein 11A

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZC3H11A antibody (AB241612)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZC3H11A antibody (AB241612)

Formalin-fixed, paraffin-embedded human prostate carcinoma tissue stained for ZC3H11A using ab241612 at 1/1000 dilution in immunohistochemical analysis. DAB staining.

Supplier Data

Immunoprecipitation - Anti-ZC3H11A antibody (AB241612)

ZC3H11A was immunoprecipitated from HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate (1 mg for IP, 20% of IP loaded) with ab241612 at 3 μg/mg lysate. Western blot was performed from the immunoprecipitate using ab241612 at 0.1 μg/ml.

Lane 1 : ab241612 IP in HeLa whole cell lysate.
Lane 2 : Control IgG IP in HeLa whole cell lysate.

Detection : Chemiluminescence with exposure time of 3 seconds.

All lanes:

Immunoprecipitation - Anti-ZC3H11A antibody (ab241612)

Predicted band size: 89 kDa

false

Supplier Data

Western blot - Anti-ZC3H11A antibody (AB241612)

All lanes:

Western blot - Anti-ZC3H11A antibody (ab241612) at 0.04 µg/mL

Lane 1:

HeLa (human epithelial cell line from cervix adenocarcinoma) cell lysate at 50 µg

Lane 2:

HeLa cell lysate at 15 µg

Lane 3:

HeLa cell lysate at 5 µg

Predicted band size: 89 kDa

true

Exposure time: 3s

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

WB, IHC-P, IP

applications

免疫原

Synthetic Peptide within Human ZC3H11A aa 700-750. The exact immunogen used to generate this antibody is proprietary information.

O75152

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/1000", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "2-5 µg/mg of lysate", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "IP-species-checked": "predicted", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

纯化说明

Antibody was affinity purified using an epitope specific to ZC3H11A immobilized on solid support.

存储溶液

pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

ZC3H11A also known as zinc finger CCCH-type containing 11A is a protein encoded by the ZC3H11A gene. With a molecular mass of approximately 97 kDa this protein can be found expressed in various tissues with elevated levels in the brain heart and liver. Mechanically ZC3H11A functions as an RNA-binding protein participating in interactions with mRNA molecules. It contains a zinc finger domain that facilitates its interactions with nucleic acids influencing RNA stability and processing.

Biological function summary

This protein has a role in regulating mRNA stability and nuclear export. It often acts as a part of the larger mRNA export complex which includes other proteins that facilitate the transport of mRNA from the nucleus to the cytoplasm. By participating in the control of gene expression at the post-transcriptional level ZC3H11A contributes to cellular homeostasis and response to stress stimuli.

Pathways

This protein functions in the mRNA processing and transport pathways. It interacts with TREX (Transcription/Export) complex components such as Aly/REF export factor (ALYREF) to ensure proper mRNA export from the nucleus. ZC3H11A also integrates into the post-transcriptional gene regulation pathway aligning with proteins like THOC1 and THOC5 ensuring the precise control of gene expression by managing RNA fate within the cell.

Mutations or dysregulation of the ZC3H11A protein have implications in neurodegenerative diseases particularly those affecting mRNA processing and transport. For instance aberrant function of this protein has been studied in the context of Alzheimer's disease where RNA transport misregulation plays a role. ZC3H11A's connection to the THOC complex which is important in RNA metabolism links it to oncology where altered mRNA export mechanisms can contribute to cancer progression.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Through its association with TREX complex components, may participate in the export and post-transcriptional coordination of selected mRNA transcripts, including those required to maintain the metabolic processes in embryonic cells (PubMed : 22928037, PubMed : 37356722). Binds RNA (PubMed : 29610341, PubMed : 37356722).. (Microbial infection) Plays a role in efficient growth of several nuclear-replicating viruses such as HIV-1, influenza virus or herpes simplex virus 1/HHV-1. Required for efficient viral mRNA export (PubMed : 29610341). May be required for proper polyadenylation of adenovirus type 5/HAdV-5 capsid mRNA (PubMed : 37356722).

See full target information ZC3H11A

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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 15:7872 PubMed39251607

2024

Systematic identification of post-transcriptional regulatory modules.

Applications

Unspecified application

Species

Unspecified reactive species

Matvei Khoroshkin,Andrey Buyan,Martin Dodel,Albertas Navickas,Johnny Yu,Fathima Trejo,Anthony Doty,Rithvik Baratam,Shaopu Zhou,Sean B Lee,Tanvi Joshi,Kristle Garcia,Benedict Choi,Sohit Miglani,Vishvak Subramanyam,Hailey Modi,Christopher Carpenter,Daniel Markett,M Ryan Corces,Faraz K Mardakheh,Ivan V Kulakovskiy,Hani Goodarzi

Journal of oncology 2020:3181596 PubMed32565799

2020

HEATR1 Deficiency Promotes Chemoresistance via Upregulating ZNF185 and Downregulating SMAD4 in Pancreatic Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yuan Fang,Xu Han,Jianang Li,Tiantao Kuang,Wenhui Lou

View all publications

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Anti-ZC3H11A抗体

Anti-ZC3H11A antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZC3H11A antibody (AB241612)

Immunoprecipitation - Anti-ZC3H11A antibody (AB241612)

Western blot - Anti-ZC3H11A antibody (AB241612)