AB254601

Anti-ZBTB38抗体

Name: ZBTB38抗体 (ab254601)| Abcam中文官网
Brand: Abcam Limited
SKU: AB254601
Price: 5791 CNY
Availability: InStock

Anti-ZBTB38 antibody

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(1 Publication)

Rabbit Polyclonal ZBTB38 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Zinc finger and BTB domain-containing protein 38 aa 650-850.

查看别名

Zinc finger and BTB domain-containing protein 38, ZBTB38

1 Images

Immunocytochemistry/ Immunofluorescence - Anti-ZBTB38 antibody (AB254601)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ZBTB38 antibody (AB254601)

PFA fixed, Triton X-100 permeabilized U-251MG (Human brain glioma cell line) cells labeling ZBTB38 using ab254601 at 4µg/ml (green) in ICC/IF.

关键信息

宿主种属

Rabbit

克隆

Polyclonal

亚型

IgG

不含载体蛋白

反应种属

Human

应用

ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human Zinc finger and BTB domain-containing protein 38 aa 650-850. The exact immunogen used to generate this antibody is proprietary information.

Q8NAP3

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反应性数据

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }

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性能和储存信息

形式

Liquid

纯化工艺

Affinity purification Immunogen

存储溶液

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

运输条件

Blue Ice

分装信息

Upon delivery aliquot

储存信息

Avoid freeze / thaw cycle

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补充信息

This supplementary information is collated from multiple sources and compiled automatically.

The ZBTB38 protein also known as CIBZ (CTCFL interacting BTB zinc finger protein) functions as a transcriptional regulator with a molecular mass of approximately 149 kDa. It contains zinc finger motifs that bind to DNA sequences to modulate gene expression. ZBTB38 mostly localizes in the nucleus of cells and shows expression in human tissues such as brain heart and skeletal muscle. The presence in these tissues indicates an important role in fundamental cellular processes.

Biological function summary

The regulatory role of ZBTB38 impacts cell cycle control and differentiation. It participates in transcriptional repression or activation depending on the interacting partners. Known to form part of multisubunit complexes ZBTB38 can engage in molecular interactions that influence chromatin remodeling. Through these configurations it affects the transcriptional regulation of target genes influencing cellular functions and development pathways.

Pathways

ZBTB38 is involved in the regulation of the Wnt and MAPK signaling pathways. These pathways play a significant role in cell proliferation differentiation and survival. ZBTB38 directly interacts with proteins such as CTCF (CCCTC-binding factor) and CTCFL (CTCF-like) in these pathways influencing various cellular responses. The precise modulation of these pathways by ZBTB38 contributes to maintaining cellular homeostasis and dynamics.

Disruptions in ZBTB38 function are linked to certain cancers and developmental disorders. Abnormal expression or mutations in ZBTB38 are associated with an increased risk of neuroblastoma where it interacts with MYC a known oncogene. Additionally changes in ZBTB38 are connected with developmental syndromes possibly through its interactions with CTCF impacting gene expression profiles relevant to these conditions.

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产品实验方案

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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靶点信息

Transcriptional regulator with bimodal DNA-binding specificity. Binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to E-box elements (5'-CACGTG-3'). Can also bind specifically to a single methyl-CpG pair. Represses transcription in a methyl-CpG-dependent manner (PubMed : 16354688). Plays an important role in regulating DNA replication and common fragile sites (CFS) stability in a RBBP6- and MCM10-dependent manner; represses expression of MCM10 which plays an important role in DNA-replication (PubMed : 24726359). Acts as a transcriptional activator. May be involved in the differentiation and/or survival of late postmitotic neurons (By similarity).

See full target information Zinc finger and BTB domain-containing protein 38

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Life science alliance 6: PubMed37604583

2023

Tumor necrosis factor mediates USE1-independent FAT10ylation under inflammatory conditions.

Applications

Unspecified application

Species

Unspecified reactive species

Leonie Schnell,Alina Zubrod,Nicola Catone,Johanna Bialas,Annette Aichem

View all publications

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Anti-ZBTB38抗体

Anti-ZBTB38 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ZBTB38 antibody (AB254601)